Pearson RC - Search Results

1

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

Wienert B, Funnell AP, Norton LJ, Pearson RC, Wilkinson-White LE, Lester K, Vadolas J, Porteus MH, Matthews JM, Quinlan KG, Crossley M. Wienert B, et al. Among authors: pearson rc. Nat Commun. 2015 May 14;6:7085. doi: 10.1038/ncomms8085. Nat Commun. 2015. PMID: 25971621 Free article.

2

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.

Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M. Martyn GE, et al. Nat Genet. 2018 Apr;50(4):498-503. doi: 10.1038/s41588-018-0085-0. Epub 2018 Apr 2. Nat Genet. 2018. PMID: 29610478

3

The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).

Pearson RC, Funnell AP, Crossley M. Pearson RC, et al. IUBMB Life. 2011 Feb;63(2):86-93. doi: 10.1002/iub.422. Epub 2011 Feb 24. IUBMB Life. 2011. PMID: 21360637 Free article. Review.

4

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.

Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T, Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam PP, Pearson RC, Crossley M. Funnell AP, et al. Among authors: pearson rc. Mol Cell Biol. 2013 Aug;33(15):2976-87. doi: 10.1128/MCB.00074-13. Epub 2013 May 28. Mol Cell Biol. 2013. PMID: 23716600 Free PMC article.

5

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor.

Burdach J, Funnell AP, Mak KS, Artuz CM, Wienert B, Lim WF, Tan LY, Pearson RC, Crossley M. Burdach J, et al. Among authors: pearson rc. Nucleic Acids Res. 2014 Jan;42(1):276-89. doi: 10.1093/nar/gkt895. Epub 2013 Oct 7. Nucleic Acids Res. 2014. PMID: 24106088 Free PMC article.

6

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.

Funnell AP, Vernimmen D, Lim WF, Mak KS, Wienert B, Martyn GE, Artuz CM, Burdach J, Quinlan KG, Higgs DR, Whitelaw E, Pearson RC, Crossley M. Funnell AP, et al. Among authors: pearson rc. BMC Mol Biol. 2014 May 16;15:8. doi: 10.1186/1471-2199-15-8. BMC Mol Biol. 2014. PMID: 24885809 Free PMC article.

7

Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain.

Lim WF, Burdach J, Funnell AP, Pearson RC, Quinlan KG, Crossley M. Lim WF, et al. Among authors: pearson rc. Nucleic Acids Res. 2016 Apr 20;44(7):3118-30. doi: 10.1093/nar/gkv1380. Epub 2015 Dec 15. Nucleic Acids Res. 2016. PMID: 26673701 Free PMC article.

8

Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).

Knights AJ, Yik JJ, Mat Jusoh H, Norton LJ, Funnell AP, Pearson RC, Bell-Anderson KS, Crossley M, Quinlan KG. Knights AJ, et al. Among authors: pearson rc. J Biol Chem. 2016 Jul 29;291(31):16048-58. doi: 10.1074/jbc.M116.715748. Epub 2016 May 24. J Biol Chem. 2016. PMID: 27226561 Free PMC article.

9

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch.

Norton LJ, Hallal S, Stout ES, Funnell APW, Pearson RCM, Crossley M, Quinlan KGR. Norton LJ, et al. Sci Rep. 2017 Jun 9;7(1):3137. doi: 10.1038/s41598-017-03289-5. Sci Rep. 2017. PMID: 28600522 Free PMC article.

10

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.

Norton LJ, Funnell APW, Burdach J, Wienert B, Kurita R, Nakamura Y, Philipsen S, Pearson RCM, Quinlan KGR, Crossley M. Norton LJ, et al. Blood Adv. 2017 Apr 25;1(11):685-692. doi: 10.1182/bloodadvances.2016002303. eCollection 2017 Apr 25. Blood Adv. 2017. PMID: 29296711 Free PMC article.

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