Valbuena GN - Search Results

1

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.

Valbuena GN, Rizzardini M, Cimini S, Siskos AP, Bendotti C, Cantoni L, Keun HC. Valbuena GN, et al. Mol Neurobiol. 2016 May;53(4):2222-40. doi: 10.1007/s12035-015-9165-7. Epub 2015 May 12. Mol Neurobiol. 2016. PMID: 25963727 Free PMC article.

2

Altered Metabolic Profiles Associate with Toxicity in SOD1^G93A Astrocyte-Neuron Co-Cultures.

Valbuena GN, Tortarolo M, Bendotti C, Cantoni L, Keun HC. Valbuena GN, et al. Sci Rep. 2017 Mar 3;7(1):50. doi: 10.1038/s41598-017-00072-4. Sci Rep. 2017. PMID: 28246392 Free PMC article.

3

Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1^G93A Amyotrophic Lateral Sclerosis.

Valbuena GN, Cantoni L, Tortarolo M, Bendotti C, Keun HC. Valbuena GN, et al. Front Neurosci. 2019 Dec 10;13:1276. doi: 10.3389/fnins.2019.01276. eCollection 2019. Front Neurosci. 2019. PMID: 31920474 Free PMC article.

4

Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.

Koufaris C, Gallage S, Yang T, Lau CH, Valbuena GN, Keun HC. Koufaris C, et al. Among authors: valbuena gn. J Proteome Res. 2016 Aug 5;15(8):2618-25. doi: 10.1021/acs.jproteome.6b00188. Epub 2016 Jul 22. J Proteome Res. 2016. PMID: 27315223 Free article.

5

Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.

Parzych K, Chinn TM, Chen Z, Loaiza S, Porsch F, Valbuena GN, Kleijnen MF, Karadimitris A, Gentleman E, Keun HC, Auner HW. Parzych K, et al. Among authors: valbuena gn. Cell Death Dis. 2015 Dec 31;6(12):e2031. doi: 10.1038/cddis.2015.373. Cell Death Dis. 2015. PMID: 26720340 Free PMC article.

6

MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data.

Rana S, Valbuena GN, Curry E, Bevan CL, Keun HC. Rana S, et al. Among authors: valbuena gn. Br J Cancer. 2022 Feb;126(3):502-513. doi: 10.1038/s41416-021-01677-3. Epub 2022 Jan 12. Br J Cancer. 2022. PMID: 35022525 Free PMC article.

7

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation.

Parzych K, Saavedra-García P, Valbuena GN, Al-Sadah HA, Robinson ME, Penfold L, Kuzeva DM, Ruiz-Tellez A, Loaiza S, Holzmann V, Caputo V, Johnson DC, Kaiser MF, Karadimitris A, Lam EW, Chevet E, Feldhahn N, Keun HC, Auner HW. Parzych K, et al. Among authors: valbuena gn. Oncogene. 2019 Apr;38(17):3216-3231. doi: 10.1038/s41388-018-0651-z. Epub 2019 Jan 9. Oncogene. 2019. PMID: 30626938 Free PMC article.

8

Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.

Koufaris C, Valbuena GN, Pomyen Y, Tredwell GD, Nevedomskaya E, Lau CH, Yang T, Benito A, Ellis JK, Keun HC. Koufaris C, et al. Among authors: valbuena gn. Oncogene. 2016 May;35(21):2766-76. doi: 10.1038/onc.2015.333. Epub 2015 Oct 19. Oncogene. 2016. PMID: 26477310 Free article.

9

Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.

Nijhuis A, Sikka A, Yogev O, Herendi L, Balcells C, Ma Y, Poon E, Eckold C, Valbuena GN, Xu Y, Liu Y, da Costa BM, Gruet M, Wickremesinghe C, Benito A, Kramer H, Montoya A, Carling D, Want EJ, Jamin Y, Chesler L, Keun HC. Nijhuis A, et al. Among authors: valbuena gn. Nat Commun. 2022 Mar 16;13(1):1380. doi: 10.1038/s41467-022-28907-3. Nat Commun. 2022. PMID: 35296644 Free PMC article.

10

The 14q32 maternally imprinted locus is a major source of longitudinally stable circulating microRNAs as measured by small RNA sequencing.

Valbuena GN, Apostolidou S, Roberts R, Barnes J, Alderton W, Harper L, Jacobs I, Menon U, Keun HC. Valbuena GN, et al. Sci Rep. 2019 Oct 31;9(1):15787. doi: 10.1038/s41598-019-51948-6. Sci Rep. 2019. PMID: 31673048 Free PMC article. Clinical Trial.

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