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pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers.
Tipping KW, Karamanos TK, Jakhria T, Iadanza MG, Goodchild SC, Tuma R, Ranson NA, Hewitt EW, Radford SE. Tipping KW, et al. Among authors: karamanos tk. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5691-6. doi: 10.1073/pnas.1423174112. Epub 2015 Apr 20. Proc Natl Acad Sci U S A. 2015. PMID: 25902516 Free PMC article.
Distinguishing closely related amyloid precursors using an RNA aptamer.
Sarell CJ, Karamanos TK, White SJ, Bunka DHJ, Kalverda AP, Thompson GS, Barker AM, Stockley PG, Radford SE. Sarell CJ, et al. Among authors: karamanos tk. J Biol Chem. 2014 Sep 26;289(39):26859-26871. doi: 10.1074/jbc.M114.595066. Epub 2014 Aug 6. J Biol Chem. 2014. PMID: 25100729 Free PMC article.
Mechanisms of amyloid formation revealed by solution NMR.
Karamanos TK, Kalverda AP, Thompson GS, Radford SE. Karamanos TK, et al. Prog Nucl Magn Reson Spectrosc. 2015 Aug;88-89:86-104. doi: 10.1016/j.pnmrs.2015.05.002. Epub 2015 May 27. Prog Nucl Magn Reson Spectrosc. 2015. PMID: 26282197 Free PMC article. Review.
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC. Dobson CL, et al. Among authors: karamanos tk. Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644. Sci Rep. 2016. PMID: 27995962 Free PMC article.
33 results