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The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis.
Heinzmann D, Bangert A, Müller AM, von Ungern-Sternberg SN, Emschermann F, Schönberger T, Chatterjee M, Mack AF, Klingel K, Kandolf R, Malesevic M, Borst O, Gawaz M, Langer HF, Katus H, Fischer G, May AE, Kaya Z, Seizer P. Heinzmann D, et al. Among authors: malesevic m. PLoS One. 2015 Apr 20;10(4):e0124606. doi: 10.1371/journal.pone.0124606. eCollection 2015. PLoS One. 2015. PMID: 25894208 Free PMC article.
Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo.
Seizer P, Ungern-Sternberg SN, Schönberger T, Borst O, Münzer P, Schmidt EM, Mack AF, Heinzmann D, Chatterjee M, Langer H, Malešević M, Lang F, Gawaz M, Fischer G, May AE. Seizer P, et al. Among authors: malesevic m. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):655-63. doi: 10.1161/ATVBAHA.114.305112. Epub 2014 Dec 30. Arterioscler Thromb Vasc Biol. 2015. PMID: 25550208
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.
Pasetto L, Pozzi S, Castelnovo M, Basso M, Estevez AG, Fumagalli S, De Simoni MG, Castellaneta V, Bigini P, Restelli E, Chiesa R, Trojsi F, Monsurrò MR, Callea L, Malešević M, Fischer G, Freschi M, Tortarolo M, Bendotti C, Bonetto V. Pasetto L, et al. Among authors: malesevic m. J Neurosci. 2017 Feb 8;37(6):1413-1427. doi: 10.1523/JNEUROSCI.2462-16.2016. Epub 2016 Dec 23. J Neurosci. 2017. PMID: 28011744 Free PMC article.
124 results