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A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.
Vayalil PK, Oh JY, Zhou F, Diers AR, Smith MR, Golzarian H, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Vayalil PK, et al. Among authors: zhou f. PLoS One. 2015 Mar 18;10(3):e0120460. doi: 10.1371/journal.pone.0120460. eCollection 2015. PLoS One. 2015. PMID: 25785718 Free PMC article.
Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.
Smith MR, Vayalil PK, Zhou F, Benavides GA, Beggs RR, Golzarian H, Nijampatnam B, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Smith MR, et al. Among authors: zhou f. Redox Biol. 2016 Aug;8:136-48. doi: 10.1016/j.redox.2016.01.002. Epub 2016 Jan 8. Redox Biol. 2016. PMID: 26774751 Free PMC article.
Detection of electrophile-sensitive proteins.
Wall SB, Smith MR, Ricart K, Zhou F, Vayalil PK, Oh JY, Landar A. Wall SB, et al. Among authors: zhou f. Biochim Biophys Acta. 2014 Feb;1840(2):913-22. doi: 10.1016/j.bbagen.2013.09.003. Epub 2013 Sep 8. Biochim Biophys Acta. 2014. PMID: 24021887 Free PMC article. Review.
Targeting lung cancer using an infectivity enhanced CXCR4-CRAd.
Zhu ZB, Rivera AA, Makhija SK, Lu B, Wang M, Izumi M, Cerfolio RJ, Stoff-Khalili MA, Zhou F, Takayama K, Siegal GP, Curiel DT. Zhu ZB, et al. Among authors: zhou f. Lung Cancer. 2007 Feb;55(2):145-56. doi: 10.1016/j.lungcan.2006.10.012. Epub 2006 Nov 17. Lung Cancer. 2007. PMID: 17113184 Free PMC article.
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