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Page 1
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. Zhu Y, et al. Among authors: tchkonia t. Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25754370 Free PMC article.
Altered expression of C/EBP family members results in decreased adipogenesis with aging.
Karagiannides I, Tchkonia T, Dobson DE, Steppan CM, Cummins P, Chan G, Salvatori K, Hadzopoulou-Cladaras M, Kirkland JL. Karagiannides I, et al. Among authors: tchkonia t. Am J Physiol Regul Integr Comp Physiol. 2001 Jun;280(6):R1772-80. doi: 10.1152/ajpregu.2001.280.6.R1772. Am J Physiol Regul Integr Comp Physiol. 2001. PMID: 11353682 Free article.
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes.
Tchkonia T, Giorgadze N, Pirtskhalava T, Tchoukalova Y, Karagiannides I, Forse RA, DePonte M, Stevenson M, Guo W, Han J, Waloga G, Lash TL, Jensen MD, Kirkland JL. Tchkonia T, et al. Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1286-96. doi: 10.1152/ajpregu.00653.2001. Am J Physiol Regul Integr Comp Physiol. 2002. PMID: 11959668 Free article.
Adipogenesis and aging: does aging make fat go MAD?
Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Kirkland JL, et al. Among authors: tchkonia t. Exp Gerontol. 2002 Jun;37(6):757-67. doi: 10.1016/s0531-5565(02)00014-1. Exp Gerontol. 2002. PMID: 12175476 Review.
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Tchkonia T, et al. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E267-77. doi: 10.1152/ajpendo.00265.2004. Epub 2004 Sep 21. Am J Physiol Endocrinol Metab. 2005. PMID: 15383371 Free article.
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.
Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Karagiannides I, et al. Among authors: tchkonia t. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5207-12. doi: 10.1073/pnas.0600821103. Epub 2006 Mar 20. Proc Natl Acad Sci U S A. 2006. PMID: 16549770 Free PMC article.
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL. Tchkonia T, et al. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E298-307. doi: 10.1152/ajpendo.00202.2006. Epub 2006 Sep 19. Am J Physiol Endocrinol Metab. 2007. PMID: 16985259 Free article.
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL. Guo W, et al. Among authors: tchkonia t. Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. doi: 10.1152/ajpendo.00557.2006. Epub 2006 Dec 5. Am J Physiol Endocrinol Metab. 2007. PMID: 17148751 Free article.
202 results