Flesch D - Search Results

1

Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists.

Knape T, Flesch D, Kuchler L, Sha LK, Giegerich AK, Labocha S, Ferreirós N, Schmid T, Wurglics M, Schubert-Zsilavecz M, Proschak E, Brüne B, Parnham MJ, von Knethen A. Knape T, et al. Among authors: flesch d. Eur J Pharmacol. 2015 May 15;755:16-26. doi: 10.1016/j.ejphar.2015.02.034. Epub 2015 Mar 5. Eur J Pharmacol. 2015. PMID: 25746464

2

SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.

Lamers C, Merk D, Gabler M, Flesch D, Kaiser A, Schubert-Zsilavecz M. Lamers C, et al. Among authors: flesch d. Future Med Chem. 2016;8(2):133-48. doi: 10.4155/fmc.15.178. Epub 2016 Jan 29. Future Med Chem. 2016. PMID: 26824277

3

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators.

Lamers C, Flesch D, Schubert-Zsilavecz M, Merk D. Lamers C, et al. Among authors: flesch d. Expert Opin Ther Pat. 2013 Jan;23(1):47-77. doi: 10.1517/13543776.2013.736495. Epub 2012 Nov 14. Expert Opin Ther Pat. 2013. PMID: 23151189 Review.

4

Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.

Flesch D, Gabler M, Lill A, Gomez RC, Steri R, Schneider G, Stark H, Schubert-Zsilavecz M, Merk D. Flesch D, et al. Bioorg Med Chem. 2015 Jul 1;23(13):3490-8. doi: 10.1016/j.bmc.2015.04.035. Epub 2015 Apr 18. Bioorg Med Chem. 2015. PMID: 25934227

5

SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.

Flesch D, Ness J, Lamers C, Dehm F, Popella S, Steri R, Ogorek I, Hieke M, Dannhardt G, Werz O, Weggen S, Schubert-Zsilavecz M. Flesch D, et al. Bioorg Med Chem Lett. 2015 Feb 15;25(4):841-6. doi: 10.1016/j.bmcl.2014.12.073. Epub 2014 Dec 30. Bioorg Med Chem Lett. 2015. PMID: 25575659

6

Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.

Merk D, Lamers C, Weber J, Flesch D, Gabler M, Proschak E, Schubert-Zsilavecz M. Merk D, et al. Among authors: flesch d. Bioorg Med Chem. 2015 Feb 1;23(3):499-514. doi: 10.1016/j.bmc.2014.12.013. Epub 2014 Dec 19. Bioorg Med Chem. 2015. PMID: 25583100

7

Nonacidic Farnesoid X Receptor Modulators.

Flesch D, Cheung SY, Schmidt J, Gabler M, Heitel P, Kramer J, Kaiser A, Hartmann M, Lindner M, Lüddens-Dämgen K, Heering J, Lamers C, Lüddens H, Wurglics M, Proschak E, Schubert-Zsilavecz M, Merk D. Flesch D, et al. J Med Chem. 2017 Aug 24;60(16):7199-7205. doi: 10.1021/acs.jmedchem.7b00903. Epub 2017 Aug 8. J Med Chem. 2017. PMID: 28749691

8

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

Flesch D, Merk D, Lamers C, Schubert-Zsilavecz M. Flesch D, et al. Expert Opin Ther Pat. 2013 Feb;23(2):233-67. doi: 10.1517/13543776.2013.744822. Epub 2013 Jan 4. Expert Opin Ther Pat. 2013. PMID: 23289354 Review.

9

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).

Merk D, Gabler M, Gomez RC, Flesch D, Hanke T, Kaiser A, Lamers C, Werz O, Schneider G, Schubert-Zsilavecz M. Merk D, et al. Among authors: flesch d. Bioorg Med Chem. 2014 Apr 15;22(8):2447-60. doi: 10.1016/j.bmc.2014.02.053. Epub 2014 Mar 15. Bioorg Med Chem. 2014. PMID: 24685112

10

Synthesis of imidazo[1,2-a]pyridines in a sequential one-pot Groebke-Blackburn modification using 2-aminopyridines, aldehydes and amines.

Flesch D, Schubert-Zsilavecz M. Flesch D, et al. Pharmazie. 2015 Aug;70(8):507-10. Pharmazie. 2015. PMID: 26380518

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