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Page 1
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.
Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ, Waldmann H. Akbulut Y, et al. Among authors: gaunt hj. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. doi: 10.1002/anie.201411511. Epub 2015 Feb 23. Angew Chem Int Ed Engl. 2015. PMID: 25707820 Free PMC article.
Natural and synthetic flavonoid modulation of TRPC5 channels.
Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CW, Muraki K, Beech DJ, Bon RS. Naylor J, et al. Among authors: gaunt hj. Br J Pharmacol. 2016 Feb;173(3):562-74. doi: 10.1111/bph.13387. Epub 2016 Jan 13. Br J Pharmacol. 2016. PMID: 26565375 Free PMC article.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. Rubaiy HN, et al. Among authors: gaunt hj. J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21. J Biol Chem. 2017. PMID: 28325835 Free PMC article.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: gaunt hj. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
Chuntharpursat-Bon E, Povstyan OV, Ludlow MJ, Carrier DJ, Debant M, Shi J, Gaunt HJ, Bauer CC, Curd A, Simon Futers T, Baxter PD, Peckham M, Muench SP, Adamson A, Humphreys N, Tumova S, Bon RS, Cubbon R, Lichtenstein L, Beech DJ. Chuntharpursat-Bon E, et al. Among authors: gaunt hj. Commun Biol. 2023 Apr 1;6(1):358. doi: 10.1038/s42003-023-04706-4. Commun Biol. 2023. PMID: 37005489 Free PMC article.
Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.
Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ. Webster PJ, et al. Among authors: gaunt hj. Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039. Oncotarget. 2017. PMID: 28178688 Free PMC article.
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