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Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.
von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. von Montfort C, et al. Among authors: kaplowitz n. J Hepatol. 2012 Oct;57(4):852-9. doi: 10.1016/j.jhep.2012.05.024. Epub 2012 Jun 9. J Hepatol. 2012. PMID: 22687340 Free PMC article.
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.
Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. Fernandez A, et al. Among authors: kaplowitz n. J Hepatol. 2013 Oct;59(4):805-13. doi: 10.1016/j.jhep.2013.05.023. Epub 2013 May 23. J Hepatol. 2013. PMID: 23707365 Free PMC article.
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Fucho R, Martínez L, Baulies A, Torres S, Tarrats N, Fernandez A, Ribas V, Astudillo AM, Balsinde J, Garcia-Rovés P, Elena M, Bergheim I, Lotersztajn S, Trautwein C, Appelqvist H, Paton AW, Paton JC, Czaja MJ, Kaplowitz N, Fernandez-Checa JC, García-Ruiz C. Fucho R, et al. Among authors: kaplowitz n. J Hepatol. 2014 Nov;61(5):1126-34. doi: 10.1016/j.jhep.2014.06.009. Epub 2014 Jun 16. J Hepatol. 2014. PMID: 24946279 Free PMC article.
342 results