Abulwerdi FA - Search Results

1

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.

Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi FA, Chan RJ, Patel JP, Tallman MS, Paietta E, Melnick A, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG. Chen L, et al. Among authors: abulwerdi fa. Leukemia. 2015 Jun;29(6):1290-300. doi: 10.1038/leu.2015.18. Epub 2015 Feb 4. Leukemia. 2015. PMID: 25650089 Free PMC article.

2

Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes.

Burrer CM, Auburn H, Wang X, Luo J, Abulwerdi FA, Nikolovska-Coleska Z, Chan GC. Burrer CM, et al. Among authors: abulwerdi fa. Antiviral Res. 2017 Feb;138:40-46. doi: 10.1016/j.antiviral.2016.11.027. Epub 2016 Nov 30. Antiviral Res. 2017. PMID: 27914937 Free PMC article.

3

3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.

Abulwerdi FA, Liao C, Mady AS, Gavin J, Shen C, Cierpicki T, Stuckey JA, Showalter HD, Nikolovska-Coleska Z. Abulwerdi FA, et al. J Med Chem. 2014 May 22;57(10):4111-33. doi: 10.1021/jm500010b. Epub 2014 May 7. J Med Chem. 2014. PMID: 24749893 Free PMC article.

4

BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.

Cojohari O, Burrer CM, Peppenelli MA, Abulwerdi FA, Nikolovska-Coleska Z, Chan GC. Cojohari O, et al. Among authors: abulwerdi fa. J Virol. 2015 May;89(10):5739-46. doi: 10.1128/JVI.00236-15. Epub 2015 Mar 4. J Virol. 2015. PMID: 25740993 Free PMC article.

5

Targeting mcl-1 for radiosensitization of pancreatic cancers.

Wei D, Zhang Q, Schreiber JS, Parsels LA, Abulwerdi FA, Kausar T, Lawrence TS, Sun Y, Nikolovska-Coleska Z, Morgan MA. Wei D, et al. Among authors: abulwerdi fa. Transl Oncol. 2015 Feb;8(1):47-54. doi: 10.1016/j.tranon.2014.12.004. Transl Oncol. 2015. PMID: 25749177 Free PMC article.

6

Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening.

Mady ASA, Liao C, Bajwa N, Kump KJ, Abulwerdi FA, Lev KL, Miao L, Grigsby SM, Perdih A, Stuckey JA, Du Y, Fu H, Nikolovska-Coleska Z. Mady ASA, et al. Among authors: abulwerdi fa. Sci Rep. 2018 Jul 5;8(1):10210. doi: 10.1038/s41598-018-27899-9. Sci Rep. 2018. PMID: 29976942 Free PMC article.

7

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.

Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, Nikolovska-Coleska Z. Kump KJ, et al. Among authors: abulwerdi fa. J Med Chem. 2020 Mar 12;63(5):2489-2510. doi: 10.1021/acs.jmedchem.9b01442. Epub 2020 Feb 14. J Med Chem. 2020. PMID: 31971799 Free PMC article.

8

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo.

Abulwerdi F, Liao C, Liu M, Azmi AS, Aboukameel A, Mady AS, Gulappa T, Cierpicki T, Owens S, Zhang T, Sun D, Stuckey JA, Mohammad RM, Nikolovska-Coleska Z. Abulwerdi F, et al. Mol Cancer Ther. 2014 Mar;13(3):565-75. doi: 10.1158/1535-7163.MCT-12-0767. Epub 2013 Sep 9. Mol Cancer Ther. 2014. PMID: 24019208 Free PMC article.

9

Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA.

Abulwerdi FA, Shortridge MD, Sztuba-Solinska J, Wilson R, Le Grice SF, Varani G, Schneekloth JS Jr. Abulwerdi FA, et al. J Med Chem. 2016 Dec 22;59(24):11148-11160. doi: 10.1021/acs.jmedchem.6b01450. Epub 2016 Dec 2. J Med Chem. 2016. PMID: 28002966 Free PMC article.

10

Discovery of RNA Binding Small Molecules Using Small Molecule Microarrays.

Connelly CM, Abulwerdi FA, Schneekloth JS Jr. Connelly CM, et al. Among authors: abulwerdi fa. Methods Mol Biol. 2017;1518:157-175. doi: 10.1007/978-1-4939-6584-7_11. Methods Mol Biol. 2017. PMID: 27873206 Free PMC article.

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