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Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways.
Valli A, Rodriguez M, Moutsianas L, Fischer R, Fedele V, Huang HL, Van Stiphout R, Jones D, Mccarthy M, Vinaxia M, Igarashi K, Sato M, Soga T, Buffa F, Mccullagh J, Yanes O, Harris A, Kessler B. Valli A, et al. Among authors: mccullagh j. Oncotarget. 2015 Feb 10;6(4):1920-41. doi: 10.18632/oncotarget.3058. Oncotarget. 2015. PMID: 25605240 Free PMC article.
Trehalose-6-phosphate signaling regulates lateral root formation in Arabidopsis thaliana.
Morales-Herrera S, Jourquin J, Coppé F, Lopez-Galvis L, De Smet T, Safi A, Njo M, Griffiths CA, Sidda JD, Mccullagh JSO, Xue X, Davis BG, Van der Eycken J, Paul MJ, Van Dijck P, Beeckman T. Morales-Herrera S, et al. Among authors: mccullagh jso. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2302996120. doi: 10.1073/pnas.2302996120. Epub 2023 Sep 25. Proc Natl Acad Sci U S A. 2023. PMID: 37748053 Free PMC article.
Optimal translational termination requires C4 lysyl hydroxylation of eRF1.
Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML. Feng T, et al. Among authors: mccullagh js. Mol Cell. 2014 Feb 20;53(4):645-54. doi: 10.1016/j.molcel.2013.12.028. Epub 2014 Jan 30. Mol Cell. 2014. PMID: 24486019 Free PMC article.
Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.
Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard PJ, Soga T, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, Szele FG, Tomlinson I. Bardella C, et al. Among authors: mccullagh js. Cancer Cell. 2016 Oct 10;30(4):578-594. doi: 10.1016/j.ccell.2016.08.017. Epub 2016 Sep 29. Cancer Cell. 2016. PMID: 27693047 Free PMC article.
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
Bailey J, Shaw A, Fischer R, Ryan BJ, Kessler BM, McCullagh J, Wade-Martins R, Channon KM, Crabtree MJ. Bailey J, et al. Among authors: mccullagh j. Free Radic Biol Med. 2017 Mar;104:214-225. doi: 10.1016/j.freeradbiomed.2017.01.012. Epub 2017 Jan 17. Free Radic Biol Med. 2017. PMID: 28104455 Free PMC article.
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, Hale A, Starr A, Nandi M, Stylianou E, McShane H, Davis S, Fischer R, Kessler BM, McCullagh J, Channon KM, Crabtree MJ. Bailey JD, et al. Among authors: mccullagh j. Cell Rep. 2019 Jul 2;28(1):218-230.e7. doi: 10.1016/j.celrep.2019.06.018. Cell Rep. 2019. PMID: 31269442 Free PMC article.
Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.
Zois CE, Hendriks AM, Haider S, Pires E, Bridges E, Kalamida D, Voukantsis D, Lagerholm BC, Fehrmann RSN, den Dunnen WFA, Tarasov AI, Baba O, Morris J, Buffa FM, McCullagh JSO, Jalving M, Harris AL. Zois CE, et al. Among authors: mccullagh jso. Cell Death Dis. 2022 Jun 28;13(6):573. doi: 10.1038/s41419-022-05005-2. Cell Death Dis. 2022. PMID: 35764612 Free PMC article.
157 results