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Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.
J Biol Chem. 2015 Feb 20;290(8):4573-4589. doi: 10.1074/jbc.M114.595181. Epub 2014 Dec 31.
J Biol Chem. 2015.
PMID: 25552479
Free PMC article.
Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton's Tyrosine Kinase.
Harris CM, Foley SE, Goedken ER, Michalak M, Murdock S, Wilson NS.
Harris CM, et al.
SLAS Discov. 2018 Dec;23(10):1040-1050. doi: 10.1177/2472555218787445. Epub 2018 Jul 10.
SLAS Discov. 2018.
PMID: 29991334
Free article.
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Transmembrane TNF-dependent uptake of anti-TNF antibodies.
Deora A, Hegde S, Lee J, Choi CH, Chang Q, Lee C, Eaton L, Tang H, Wang D, Lee D, Michalak M, Tomlinson M, Tao Q, Gaur N, Harvey B, McLoughlin S, Labkovsky B, Ghayur T.
Deora A, et al.
MAbs. 2017 May/Jun;9(4):680-695. doi: 10.1080/19420862.2017.1304869. Epub 2017 Mar 21.
MAbs. 2017.
PMID: 28323513
Free PMC article.
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