Leake D - Search Results

1

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates.

Cuellar TL, Barnes D, Nelson C, Tanguay J, Yu SF, Wen X, Scales SJ, Gesch J, Davis D, van Brabant Smith A, Leake D, Vandlen R, Siebel CW. Cuellar TL, et al. Among authors: leake d. Nucleic Acids Res. 2015 Jan;43(2):1189-203. doi: 10.1093/nar/gku1362. Epub 2014 Dec 30. Nucleic Acids Res. 2015. PMID: 25550431 Free PMC article.

2

Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens.

Strezoska Ž, Licon A, Haimes J, Spayd KJ, Patel KM, Sullivan K, Jastrzebski K, Simpson KJ, Leake D, van Brabant Smith A, Vermeulen A. Strezoska Ž, et al. Among authors: leake d. PLoS One. 2012;7(8):e42341. doi: 10.1371/journal.pone.0042341. Epub 2012 Aug 1. PLoS One. 2012. PMID: 22870320 Free PMC article.

3

Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.

Mutisya D, Selvam C, Lunstad BD, Pallan PS, Haas A, Leake D, Egli M, Rozners E. Mutisya D, et al. Among authors: leake d. Nucleic Acids Res. 2014 Jun;42(10):6542-51. doi: 10.1093/nar/gku235. Epub 2014 May 9. Nucleic Acids Res. 2014. PMID: 24813446 Free PMC article.

4

Rational siRNA design for RNA interference.

Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Reynolds A, et al. Among authors: leake d. Nat Biotechnol. 2004 Mar;22(3):326-30. doi: 10.1038/nbt936. Epub 2004 Feb 1. Nat Biotechnol. 2004. PMID: 14758366 Free article.

5

Off-target effects by siRNA can induce toxic phenotype.

Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A. Fedorov Y, et al. Among authors: leake d. RNA. 2006 Jul;12(7):1188-96. doi: 10.1261/rna.28106. Epub 2006 May 8. RNA. 2006. PMID: 16682561 Free PMC article.

6

A protocol for designing siRNAs with high functionality and specificity.

Birmingham A, Anderson E, Sullivan K, Reynolds A, Boese Q, Leake D, Karpilow J, Khvorova A. Birmingham A, et al. Among authors: leake d. Nat Protoc. 2007;2(9):2068-78. doi: 10.1038/nprot.2007.278. Nat Protoc. 2007. PMID: 17853862

7

Experimental validation of the importance of seed complement frequency to siRNA specificity.

Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova E, Leake D, Fedorov Y, Karpilow J, Khvorova A. Anderson EM, et al. Among authors: leake d. RNA. 2008 May;14(5):853-61. doi: 10.1261/rna.704708. Epub 2008 Mar 26. RNA. 2008. PMID: 18367722 Free PMC article.

8

Induction of the interferon response by siRNA is cell type- and duplex length-dependent.

Reynolds A, Anderson EM, Vermeulen A, Fedorov Y, Robinson K, Leake D, Karpilow J, Marshall WS, Khvorova A. Reynolds A, et al. Among authors: leake d. RNA. 2006 Jun;12(6):988-93. doi: 10.1261/rna.2340906. Epub 2006 Apr 12. RNA. 2006. PMID: 16611941 Free PMC article.

9

Mechanistic insights aid computational short interfering RNA design.

Boese Q, Leake D, Reynolds A, Read S, Scaringe SA, Marshall WS, Khvorova A. Boese Q, et al. Among authors: leake d. Methods Enzymol. 2005;392:73-96. doi: 10.1016/S0076-6879(04)92005-8. Methods Enzymol. 2005. PMID: 15644176

10

Biodegradable nanoparticles with sustained release of functional siRNA in skin.

Jacobson GB, Gonzalez-Gonzalez E, Spitler R, Shinde R, Leake D, Kaspar RL, Contag CH, Zare RN. Jacobson GB, et al. Among authors: leake d. J Pharm Sci. 2010 Oct;99(10):4261-6. doi: 10.1002/jps.22147. J Pharm Sci. 2010. PMID: 20737633

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