Zhang T - Search Results

1

Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.

Yang B, Lamb ML, Zhang T, Hennessy EJ, Grewal G, Sha L, Zambrowski M, Block MH, Dowling JE, Su N, Wu J, Deegan T, Mikule K, Wang W, Kaspera R, Chuaqui C, Chen H. Yang B, et al. Among authors: zhang t. J Med Chem. 2014 Dec 11;57(23):9958-70. doi: 10.1021/jm501179r. Epub 2014 Dec 2. J Med Chem. 2014. PMID: 25458601

2

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

Dakin LA, Block MH, Chen H, Code E, Dowling JE, Feng X, Ferguson AD, Green I, Hird AW, Howard T, Keeton EK, Lamb ML, Lyne PD, Pollard H, Read J, Wu AJ, Zhang T, Zheng X. Dakin LA, et al. Among authors: zhang t. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. doi: 10.1016/j.bmcl.2012.05.098. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22727640

3

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.

Dowling JE, Chuaqui C, Pontz TW, Lyne PD, Larsen NA, Block MH, Chen H, Su N, Wu A, Russell D, Pollard H, Lee JW, Peng B, Thakur K, Ye Q, Zhang T, Brassil P, Racicot V, Bao L, Denz CR, Cooke E. Dowling JE, et al. Among authors: zhang t. ACS Med Chem Lett. 2012 Jan 24;3(4):278-83. doi: 10.1021/ml200257n. eCollection 2012 Apr 12. ACS Med Chem Lett. 2012. PMID: 24900464 Free PMC article.

4

Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.

Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA, Peng B, Pontz TW, Rivard-Costa C, Saeh JC, Thakur K, Ye Q, Zhang T, Lyne PD. Dowling JE, et al. Among authors: zhang t. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. doi: 10.1021/ml400197u. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900749 Free PMC article.

5

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.

Gao S, Song L, Claff T, Woodson M, Sylvester K, Jing L, Weiße RH, Cheng Y, Sträter N, Schäkel L, Gütschow M, Ye B, Yang M, Zhang T, Kang D, Toth K, Tavis J, Tollefson AE, Müller CE, Zhan P, Liu X. Gao S, et al. Among authors: zhang t. J Med Chem. 2022 Dec 22;65(24):16902-16917. doi: 10.1021/acs.jmedchem.2c01716. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475694

6

5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.

Song H, Xia Y, Zhang T, Dun C, Meng B, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Song H, et al. Among authors: zhang t. Eur J Med Chem. 2023 Nov 5;259:115686. doi: 10.1016/j.ejmech.2023.115686. Epub 2023 Jul 29. Eur J Med Chem. 2023. PMID: 37536208

7

Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.

Sun Y, Zhou Z, Feng D, Jing L, Zhao F, Wang Z, Zhang T, Lin H, Song H, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Sun Y, et al. Among authors: zhang t. J Med Chem. 2022 Dec 8;65(23):15608-15626. doi: 10.1021/acs.jmedchem.2c00576. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36411036

8

Design and synthesis of fascaplysin derivatives as inhibitors of FtsZ with potent antibacterial activity and mechanistic study.

Qiu H, Zhao X, Jiang Y, Liang W, Wang W, Jiang X, Jiang M, Wang X, Cui W, Li Y, Tang K, Zhang T, Zhao L, Liang H. Qiu H, et al. Among authors: zhang t. Eur J Med Chem. 2023 Jun 5;254:115348. doi: 10.1016/j.ejmech.2023.115348. Epub 2023 Apr 11. Eur J Med Chem. 2023. PMID: 37060755

9

In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.

Sun Y, Feng D, Zhou Z, Zhang T, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Sun Y, et al. Among authors: zhang t. Bioorg Med Chem. 2023 Dec 15;96:117484. doi: 10.1016/j.bmc.2023.117484. Epub 2023 Sep 23. Bioorg Med Chem. 2023. PMID: 37976805

10

Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.

Faridoon, Zheng J, Zhang T, Tong S, Liu T, Cui J, Xu H, Hu D, Shen Y, Yin Y, Zhao D, Tan C, Dong X, Chen J, Ji F, Tong C, Li JJ, Li J, Zhang G. Faridoon, et al. Among authors: zhang g, zhang t. J Med Chem. 2024 Jun 13;67(11):9431-9446. doi: 10.1021/acs.jmedchem.4c00552. Epub 2024 May 31. J Med Chem. 2024. PMID: 38818879

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