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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17. Nat Cell Biol. 2014. PMID: 25402683 Free PMC article.
Quantitative assays for esterified oxylipins generated by immune cells.
Morgan AH, Hammond VJ, Morgan L, Thomas CP, Tallman KA, Garcia-Diaz YR, McGuigan C, Serpi M, Porter NA, Murphy RC, O'Donnell VB. Morgan AH, et al. Nat Protoc. 2010 Dec;5(12):1919-31. doi: 10.1038/nprot.2010.162. Epub 2010 Nov 10. Nat Protoc. 2010. PMID: 21127486 Free PMC article.
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.
Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB. Hammond VJ, et al. J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11. J Biol Chem. 2012. PMID: 23060450 Free PMC article. Clinical Trial.
Interleukin-6 signaling drives fibrosis in unresolved inflammation.
Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA. Fielding CA, et al. Immunity. 2014 Jan 16;40(1):40-50. doi: 10.1016/j.immuni.2013.10.022. Epub 2014 Jan 9. Immunity. 2014. PMID: 24412616 Free PMC article.
A novel role for 12/15-lipoxygenase in regulating autophagy.
Morgan AH, Hammond VJ, Sakoh-Nakatogawa M, Ohsumi Y, Thomas CP, Blanchet F, Piguet V, Kiselyov K, O'Donnell VB. Morgan AH, et al. Redox Biol. 2015;4:40-7. doi: 10.1016/j.redox.2014.11.005. Epub 2014 Dec 3. Redox Biol. 2015. PMID: 25498966 Free PMC article.
168 results