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Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
McIver EG, Bryans J, Birchall K, Chugh J, Drake T, Lewis SJ, Osborne J, Smiljanic-Hurley E, Tsang W, Kamal A, Levy A, Newman M, Taylor D, Arthur JS, Clark K, Cohen P. McIver EG, et al. Among authors: chugh j. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73. doi: 10.1016/j.bmcl.2012.09.063. Epub 2012 Sep 28. Bioorg Med Chem Lett. 2012. PMID: 23099093
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS. Lougheed KE, et al. Among authors: chugh j. Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/j.tube.2011.03.005. Epub 2011 Apr 11. Tuberculosis (Edinb). 2011. PMID: 21482481 Free PMC article.
76 results