Pantsar T - Search Results

1

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT. Savinainen JR, et al. Among authors: pantsar t. Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19. Mol Pharmacol. 2014. PMID: 25140003

2

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT. Aaltonen N, et al. Among authors: pantsar t. Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012. Chem Biol. 2013. PMID: 23521796

3

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR. Laitinen T, et al. Among authors: pantsar t. Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24. Mol Pharmacol. 2014. PMID: 24368842

4

Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.

Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. Pantsar T, et al. Eur J Pharm Sci. 2017 Sep 30;107:97-111. doi: 10.1016/j.ejps.2017.07.002. Epub 2017 Jul 5. Eur J Pharm Sci. 2017. PMID: 28687529

5

The use of molecular descriptors in the development of co-amorphous formulations.

Meng-Lund H, Kasten G, Jensen KT, Poso A, Pantsar T, Rades T, Rantanen J, Grohganz H. Meng-Lund H, et al. Among authors: pantsar t. Eur J Pharm Sci. 2018 Jul 1;119:31-38. doi: 10.1016/j.ejps.2018.04.014. Epub 2018 Apr 10. Eur J Pharm Sci. 2018. PMID: 29649569

6

Binding Affinity via Docking: Fact and Fiction.

Pantsar T, Poso A. Pantsar T, et al. Molecules. 2018 Jul 30;23(8):1899. doi: 10.3390/molecules23081899. Molecules. 2018. PMID: 30061498 Free PMC article.

7

Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling.

Pantsar T, Rissanen S, Dauch D, Laitinen T, Vattulainen I, Poso A. Pantsar T, et al. PLoS Comput Biol. 2018 Sep 10;14(9):e1006458. doi: 10.1371/journal.pcbi.1006458. eCollection 2018 Sep. PLoS Comput Biol. 2018. PMID: 30199525 Free PMC article.

8

The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations.

Shevchenko E, Poso A, Pantsar T. Shevchenko E, et al. Among authors: pantsar t. Comput Struct Biotechnol J. 2020 Sep 20;18:2687-2698. doi: 10.1016/j.csbj.2020.09.017. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 33101607 Free PMC article.

9

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L. Dauch D, et al. Among authors: pantsar t. Nat Med. 2016 Jul;22(7):744-53. doi: 10.1038/nm.4107. Epub 2016 May 23. Nat Med. 2016. PMID: 27213815

10

Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors.

Heider F, Ansideri F, Tesch R, Pantsar T, Haun U, Döring E, Kudolo M, Poso A, Albrecht W, Laufer SA, Koch P. Heider F, et al. Among authors: pantsar t. Eur J Med Chem. 2019 Aug 1;175:309-329. doi: 10.1016/j.ejmech.2019.04.035. Epub 2019 Apr 24. Eur J Med Chem. 2019. PMID: 31096153

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