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Page 1
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.
Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IOC, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EMC, Partridge L, Isaacs AM. Mizielinska S, et al. Among authors: niccoli t. Science. 2014 Sep 5;345(6201):1192-1194. doi: 10.1126/science.1256800. Epub 2014 Aug 7. Science. 2014. PMID: 25103406 Free PMC article.
Ageing as a risk factor for disease.
Niccoli T, Partridge L. Niccoli T, et al. Curr Biol. 2012 Sep 11;22(17):R741-52. doi: 10.1016/j.cub.2012.07.024. Curr Biol. 2012. PMID: 22975005 Free article. Review.
Cell-nonautonomous effects of dFOXO/DAF-16 in aging.
Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L. Alic N, et al. Among authors: niccoli t. Cell Rep. 2014 Feb 27;6(4):608-16. doi: 10.1016/j.celrep.2014.01.015. Epub 2014 Feb 6. Cell Rep. 2014. PMID: 24508462 Free PMC article.
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.
Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L. Niccoli T, et al. Curr Biol. 2016 Sep 12;26(17):2291-300. doi: 10.1016/j.cub.2016.07.017. Epub 2016 Aug 11. Curr Biol. 2016. PMID: 27524482 Free PMC article.
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.
Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L. Niccoli T, et al. Curr Biol. 2016 Sep 26;26(18):2550. doi: 10.1016/j.cub.2016.09.018. Epub 2016 Sep 26. Curr Biol. 2016. PMID: 27676294 Free PMC article. No abstract available.
Ageing as a risk factor for ALS/FTD.
Niccoli T, Partridge L, Isaacs AM. Niccoli T, et al. Hum Mol Genet. 2017 Oct 1;26(R2):R105-R113. doi: 10.1093/hmg/ddx247. Hum Mol Genet. 2017. PMID: 28977441 Review.
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM. Simone R, et al. Among authors: niccoli t. EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850. EMBO Mol Med. 2018. PMID: 29113975 Free PMC article.
Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.
Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE, Grönke S, Esser J, Heslegrave A, Zetterberg H, Partridge L, Isaacs AM. Moens TG, et al. Among authors: niccoli t. Acta Neuropathol. 2018 Mar;135(3):445-457. doi: 10.1007/s00401-017-1798-3. Epub 2018 Jan 29. Acta Neuropathol. 2018. PMID: 29380049 Free PMC article.
C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.
Moens TG, Niccoli T, Wilson KM, Atilano ML, Birsa N, Gittings LM, Holbling BV, Dyson MC, Thoeng A, Neeves J, Glaria I, Yu L, Bussmann J, Storkebaum E, Pardo M, Choudhary JS, Fratta P, Partridge L, Isaacs AM. Moens TG, et al. Among authors: niccoli t. Acta Neuropathol. 2019 Mar;137(3):487-500. doi: 10.1007/s00401-018-1946-4. Epub 2019 Jan 2. Acta Neuropathol. 2019. PMID: 30604225 Free PMC article.
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats.
Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, Partridge L, Ichida JK, Isaacs AM, Petrucelli L, Gitler AD. Yamada SB, et al. Among authors: niccoli t. Nat Neurosci. 2019 Sep;22(9):1383-1388. doi: 10.1038/s41593-019-0455-7. Epub 2019 Jul 29. Nat Neurosci. 2019. PMID: 31358992 Free PMC article.
24 results