Tian H - Search Results

1

A nontumorigenic variant of FGF19 treats cholestatic liver diseases.

Luo J, Ko B, Elliott M, Zhou M, Lindhout DA, Phung V, To C, Learned RM, Tian H, DePaoli AM, Ling L. Luo J, et al. Among authors: tian h. Sci Transl Med. 2014 Jul 30;6(247):247ra100. doi: 10.1126/scitranslmed.3009098. Sci Transl Med. 2014. PMID: 25080475 Clinical Trial.

2

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.

Zhou M, Wang X, Phung V, Lindhout DA, Mondal K, Hsu JY, Yang H, Humphrey M, Ding X, Arora T, Learned RM, DePaoli AM, Tian H, Ling L. Zhou M, et al. Among authors: tian h. Cancer Res. 2014 Jun 15;74(12):3306-16. doi: 10.1158/0008-5472.CAN-14-0208. Epub 2014 Apr 11. Cancer Res. 2014. PMID: 24728076

3

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice.

Zhou M, Learned RM, Rossi SJ, DePaoli AM, Tian H, Ling L. Zhou M, et al. Among authors: tian h. Hepatology. 2016 Mar;63(3):914-29. doi: 10.1002/hep.28257. Epub 2015 Nov 30. Hepatology. 2016. PMID: 26418580 Free PMC article.

4

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15.

Zhou M, Luo J, Chen M, Yang H, Learned RM, DePaoli AM, Tian H, Ling L. Zhou M, et al. Among authors: tian h. J Hepatol. 2017 Jun;66(6):1182-1192. doi: 10.1016/j.jhep.2017.01.027. Epub 2017 Feb 9. J Hepatol. 2017. PMID: 28189755 Free article.

5

Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.

Zhou M, Yang H, Learned RM, Tian H, Ling L. Zhou M, et al. Among authors: tian h. Nat Commun. 2017 May 16;8:15433. doi: 10.1038/ncomms15433. Nat Commun. 2017. PMID: 28508871 Free PMC article.

6

Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis.

Zhou M, Learned RM, Rossi SJ, Tian H, DePaoli AM, Ling L. Zhou M, et al. Among authors: tian h. J Lipid Res. 2019 Mar;60(3):550-565. doi: 10.1194/jlr.M089961. Epub 2019 Jan 24. J Lipid Res. 2019. PMID: 30679232 Free PMC article.

7

FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis.

DePaoli AM, Zhou M, Kaplan DD, Hunt SC, Adams TD, Learned RM, Tian H, Ling L. DePaoli AM, et al. Among authors: tian h. Diabetes. 2019 Jun;68(6):1315-1328. doi: 10.2337/db18-1305. Epub 2019 Mar 12. Diabetes. 2019. PMID: 30862680 Clinical Trial.

8

Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice.

Zhou M, Learned RM, Rossi SJ, DePaoli AM, Tian H, Ling L. Zhou M, et al. Among authors: tian h. Hepatol Commun. 2017 Oct 16;1(10):1024-1042. doi: 10.1002/hep4.1108. eCollection 2017 Dec. Hepatol Commun. 2017. PMID: 29404440 Free PMC article.

9

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.

Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD. Galon-Tilleman H, et al. Among authors: tian h. J Biol Chem. 2017 Feb 3;292(5):1925-1933. doi: 10.1074/jbc.M116.748103. Epub 2016 Dec 19. J Biol Chem. 2017. PMID: 27994053 Free PMC article.

10

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB. Hsu JY, et al. Among authors: tian h. Nature. 2017 Oct 12;550(7675):255-259. doi: 10.1038/nature24042. Epub 2017 Sep 27. Nature. 2017. PMID: 28953886

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