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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C. Kleinberger G, et al. Among authors: colonna m. Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093. Sci Transl Med. 2014. PMID: 24990881
Efficient colonic mucosal wound repair requires Trem2 signaling.
Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS. Seno H, et al. Among authors: colonna m. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):256-61. doi: 10.1073/pnas.0803343106. Epub 2008 Dec 24. Proc Natl Acad Sci U S A. 2009. PMID: 19109436 Free PMC article.
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M. Wang Y, et al. Among authors: colonna m. Cell. 2015 Mar 12;160(6):1061-71. doi: 10.1016/j.cell.2015.01.049. Epub 2015 Feb 26. Cell. 2015. PMID: 25728668 Free PMC article.
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M. Wang Y, et al. Among authors: colonna m. J Exp Med. 2016 May 2;213(5):667-75. doi: 10.1084/jem.20151948. Epub 2016 Apr 18. J Exp Med. 2016. PMID: 27091843 Free PMC article.
Elucidating the Role of TREM2 in Alzheimer's Disease.
Ulrich JD, Ulland TK, Colonna M, Holtzman DM. Ulrich JD, et al. Among authors: colonna m. Neuron. 2017 Apr 19;94(2):237-248. doi: 10.1016/j.neuron.2017.02.042. Neuron. 2017. PMID: 28426958 Free article. Review.
1,079 results