Rajeev KG - Search Results

1

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs.

Hu J, Liu J, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Swayze EE, Lima WF, Prakash TP, Xiang Q, Martinez C, Corey DR. Hu J, et al. Among authors: rajeev kg. Biochemistry. 2014 Jul 22;53(28):4510-8. doi: 10.1021/bi500610r. Epub 2014 Jul 11. Biochemistry. 2014. PMID: 24981774 Free PMC article.

2

2'-modified-2-thiothymidine oligonucleotides.

Rajeev KG, Prakash TP, Manoharan M. Rajeev KG, et al. Org Lett. 2003 Aug 21;5(17):3005-8. doi: 10.1021/ol0348607. Org Lett. 2003. PMID: 12916967

3

Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.

Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M. Diop-Frimpong B, et al. Among authors: rajeev kg. Nucleic Acids Res. 2005 Sep 16;33(16):5297-307. doi: 10.1093/nar/gki823. Print 2005. Nucleic Acids Res. 2005. PMID: 16170156 Free PMC article.

4

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.

Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M. Li F, et al. Among authors: rajeev kg. Nucleic Acids Res. 2007;35(19):6424-38. doi: 10.1093/nar/gkm664. Epub 2007 Sep 18. Nucleic Acids Res. 2007. PMID: 17881374 Free PMC article.

5

Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA.

Alam MR, Ming X, Fisher M, Lackey JG, Rajeev KG, Manoharan M, Juliano RL. Alam MR, et al. Among authors: rajeev kg. Bioconjug Chem. 2011 Aug 17;22(8):1673-81. doi: 10.1021/bc200235q. Epub 2011 Jul 20. Bioconjug Chem. 2011. PMID: 21755983 Free PMC article.

6

Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA.

Zlatev I, Lackey JG, Zhang L, Dell A, McRae K, Shaikh S, Duncan RG, Rajeev KG, Manoharan M. Zlatev I, et al. Among authors: rajeev kg. Bioorg Med Chem. 2013 Feb 1;21(3):722-32. doi: 10.1016/j.bmc.2012.11.043. Epub 2012 Dec 3. Bioorg Med Chem. 2013. PMID: 23260577

7

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.

Liu J, Pendergraff H, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Hu J, Corey DR. Liu J, et al. Among authors: rajeev kg. Nucleic Acids Res. 2013 Oct;41(18):8788-801. doi: 10.1093/nar/gkt594. Epub 2013 Jul 24. Nucleic Acids Res. 2013. PMID: 23887934 Free PMC article.

8

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.

Nair JK, Willoughby JL, Chan A, Charisse K, Alam MR, Wang Q, Hoekstra M, Kandasamy P, Kel'in AV, Milstein S, Taneja N, O'Shea J, Shaikh S, Zhang L, van der Sluis RJ, Jung ME, Akinc A, Hutabarat R, Kuchimanchi S, Fitzgerald K, Zimmermann T, van Berkel TJ, Maier MA, Rajeev KG, Manoharan M. Nair JK, et al. Among authors: rajeev kg. J Am Chem Soc. 2014 Dec 10;136(49):16958-61. doi: 10.1021/ja505986a. Epub 2014 Dec 1. J Am Chem Soc. 2014. PMID: 25434769

9

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. Zlatev I, et al. Among authors: rajeev kg. ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13. ACS Chem Biol. 2016. PMID: 26675211

10

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.

Kel'in AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O'Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M. Kel'in AV, et al. Among authors: rajeev kg. J Org Chem. 2016 Mar 18;81(6):2261-79. doi: 10.1021/acs.joc.5b02375. Epub 2016 Mar 4. J Org Chem. 2016. PMID: 26940174

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