Heining P - Search Results

1

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.

Pan S, Gray NS, Gao W, Mi Y, Fan Y, Wang X, Tuntland T, Che J, Lefebvre S, Chen Y, Chu A, Hinterding K, Gardin A, End P, Heining P, Bruns C, Cooke NG, Nuesslein-Hildesheim B. Pan S, et al. Among authors: heining p. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. doi: 10.1021/ml300396r. eCollection 2013 Mar 14. ACS Med Chem Lett. 2013. PMID: 24900670 Free PMC article.

2

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Brinkmann V, Billich A, Baumruker T, Heining P, Schmouder R, Francis G, Aradhye S, Burtin P. Brinkmann V, et al. Among authors: heining p. Nat Rev Drug Discov. 2010 Nov;9(11):883-97. doi: 10.1038/nrd3248. Epub 2010 Oct 29. Nat Rev Drug Discov. 2010. PMID: 21031003 Review.

3

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

Meno-Tetang GM, Li H, Mis S, Pyszczynski N, Heining P, Lowe P, Jusko WJ. Meno-Tetang GM, et al. Among authors: heining p. Drug Metab Dispos. 2006 Sep;34(9):1480-7. doi: 10.1124/dmd.105.009001. Epub 2006 Jun 2. Drug Metab Dispos. 2006. PMID: 16751263

4

Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis.

Karlsson G, Francis G, Koren G, Heining P, Zhang X, Cohen JA, Kappos L, Collins W. Karlsson G, et al. Among authors: heining p. Neurology. 2014 Feb 25;82(8):674-80. doi: 10.1212/WNL.0000000000000137. Epub 2014 Jan 24. Neurology. 2014. PMID: 24463630 Free PMC article.

5

The Use of Minipig in Drug Discovery and Development: Pros and Cons of Minipig Selection and Strategies to Use as a Preferred Nonrodent Species.

Heining P, Ruysschaert T. Heining P, et al. Toxicol Pathol. 2016 Apr;44(3):467-73. doi: 10.1177/0192623315610823. Epub 2015 Dec 16. Toxicol Pathol. 2016. PMID: 26674804

6

Vehicle Systems and Excipients Used in Minipig Drug Development Studies.

Weaver ML, Grossi AB, Schützsack J, Parish J, Løgsted J, Bøgh IB, Cameron D, Harvey W, Festag M, Downes N, Venturella S, Schlichtiger J, Mhedhbi S, Ross V, Kissner T, Stark C, Milano S, Heining P, Sanchez-Felix M. Weaver ML, et al. Among authors: heining p. Toxicol Pathol. 2016 Apr;44(3):367-72. doi: 10.1177/0192623315613088. Epub 2015 Dec 16. Toxicol Pathol. 2016. PMID: 26674803 Review.

7

The Potential of Minipigs in the Development of Anticancer Therapeutics: Species Comparison and Examples of Special Applications.

Mahl A, Dincer Z, Heining P. Mahl A, et al. Among authors: heining p. Toxicol Pathol. 2016 Apr;44(3):391-7. doi: 10.1177/0192623315619040. Epub 2015 Dec 23. Toxicol Pathol. 2016. PMID: 26698323

8

Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses.

Li H, Meno-Tetang GM, Chiba K, Arima N, Heining P, Jusko WJ. Li H, et al. Among authors: heining p. J Pharmacol Exp Ther. 2002 May;301(2):519-26. doi: 10.1124/jpet.301.2.519. J Pharmacol Exp Ther. 2002. PMID: 11961052

9

The industry view on long-term toxicology testing in drug development of human pharmaceuticals.

Van Cauteren H, Bentley P, Bode G, Cordier A, Coussement W, Heining P, Sims J. Van Cauteren H, et al. Among authors: heining p. Pharmacol Toxicol. 2000;86 Suppl 1:1-5. doi: 10.1034/j.1600-0773.2000.d01-1.x. Pharmacol Toxicol. 2000. PMID: 10905744 Review.

10

Comparison of clinical pathology parameters with two different blood sampling techniques in rats: retrobulbar plexus versus sublingual vein.

Mahl A, Heining P, Ulrich P, Jakubowski J, Bobadilla M, Zeller W, Bergmann R, Singer T, Meister L. Mahl A, et al. Among authors: heining p. Lab Anim. 2000 Oct;34(4):351-61. doi: 10.1258/002367700780387787. Lab Anim. 2000. PMID: 11072855

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