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Page 1
A high-precision fluorogenic cholesteryl ester transfer protein assay compatible with animal serum and 3456-well assay technology.
Eveland SS, Milot DP, Guo Q, Chen Y, Hyland SA, Peterson LB, Jezequel-Sur S, O'Donnell GT, Zuck PD, Ferrer M, Strulovici B, Wagner JA, Tanaka WK, Hilliard DA, Laterza O, Wright SD, Sparrow CP, Anderson MS. Eveland SS, et al. Among authors: sparrow cp. Anal Biochem. 2007 Sep 15;368(2):239-49. doi: 10.1016/j.ab.2007.06.003. Epub 2007 Jun 8. Anal Biochem. 2007. PMID: 17601482
2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.
Smith CJ, Ali A, Chen L, Hammond ML, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Sinclair PJ. Smith CJ, et al. Among authors: sparrow cp. Bioorg Med Chem Lett. 2010 Jan 1;20(1):346-9. doi: 10.1016/j.bmcl.2009.10.099. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19914065
2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety.
Hunt JA, Gonzalez S, Kallashi F, Hammond ML, Pivnichny JV, Tong X, Xu SS, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Sinclair PJ. Hunt JA, et al. Among authors: sparrow cp. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1019-22. doi: 10.1016/j.bmcl.2009.12.046. Epub 2009 Dec 16. Bioorg Med Chem Lett. 2010. PMID: 20036121
Design of a novel class of biphenyl CETP inhibitors.
Lu Z, Napolitano JB, Theberge A, Ali A, Hammond ML, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ. Lu Z, et al. Among authors: sparrow cp. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7469-72. doi: 10.1016/j.bmcl.2010.10.019. Epub 2010 Oct 15. Bioorg Med Chem Lett. 2010. PMID: 21041082
2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.
Kallashi F, Kim D, Kowalchick J, Park YJ, Hunt JA, Ali A, Smith CJ, Hammond ML, Pivnichny JV, Tong X, Xu SS, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Cumiskey AM, Latham M, Peterson LB, Rosa R, Sparrow CP, Wright SD, Sinclair PJ. Kallashi F, et al. Among authors: sparrow cp. Bioorg Med Chem Lett. 2011 Jan 1;21(1):558-61. doi: 10.1016/j.bmcl.2010.10.062. Epub 2010 Oct 20. Bioorg Med Chem Lett. 2011. PMID: 21094047
2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.
Sweis RF, Hunt JA, Kallashi F, Hammond ML, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Cumiskey AM, Latham M, Rosa R, Peterson L, Sparrow CP, Wright SD, Anderson MS, Sinclair PJ. Sweis RF, et al. Among authors: sparrow cp. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1890-5. doi: 10.1016/j.bmcl.2010.11.090. Epub 2010 Nov 25. Bioorg Med Chem Lett. 2011. PMID: 21147531
Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.
Smith CJ, Ali A, Hammond ML, Li H, Lu Z, Napolitano J, Taylor GE, Thompson CF, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Cumiskey AM, Latham M, Peterson LB, Rosa R, Pivnichny JV, Tong X, Xu SS, Sinclair PJ. Smith CJ, et al. Among authors: sparrow cp. J Med Chem. 2011 Jul 14;54(13):4880-95. doi: 10.1021/jm200484c. Epub 2011 Jun 17. J Med Chem. 2011. PMID: 21682257
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
Lu Z, Chen YH, Napolitano JB, Taylor G, Ali A, Hammond ML, Deng Q, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ. Lu Z, et al. Among authors: sparrow cp. Bioorg Med Chem Lett. 2012 Jan 1;22(1):199-203. doi: 10.1016/j.bmcl.2011.11.039. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22142541
56 results