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The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J, Pack K, Payne S, Roylance R, Gorman P, Sheer D, Neale K, Phillips R, Talbot I, Bodmer W, Tomlinson I. Lamlum H, et al. Among authors: clark s. Nat Med. 1999 Sep;5(9):1071-5. doi: 10.1038/12511. Nat Med. 1999. PMID: 10470088
Gastric tumours in FAP.
Walton SJ, Frayling IM, Clark SK, Latchford A. Walton SJ, et al. Fam Cancer. 2017 Jul;16(3):363-369. doi: 10.1007/s10689-017-9966-0. Fam Cancer. 2017. PMID: 28271232 Free article.
5,245 results