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Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.
Wain LV, Sayers I, Soler Artigas M, Portelli MA, Zeggini E, Obeidat M, Sin DD, Bossé Y, Nickle D, Brandsma CA, Malarstig A, Vangjeli C, Jelinsky SA, John S, Kilty I, McKeever T, Shrine NR, Cook JP, Patel S, Spector TD, Hollox EJ, Hall IP, Tobin MD. Wain LV, et al. Among authors: kilty i. PLoS Genet. 2014 May 1;10(5):e1004314. doi: 10.1371/journal.pgen.1004314. eCollection 2014 May. PLoS Genet. 2014. PMID: 24786987 Free PMC article.
The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.
Miller S, Henry AP, Hodge E, Kheirallah AK, Billington CK, Rimington TL, Bhaker SK, Obeidat M, Melén E, Merid SK, Swan C, Gowland C, Nelson CP, Stewart CE, Bolton CE, Kilty I, Malarstig A, Parker SG, Moffatt MF, Wardlaw AJ, Hall IP, Sayers I. Miller S, et al. Among authors: kilty i. PLoS One. 2016 Oct 18;11(10):e0164041. doi: 10.1371/journal.pone.0164041. eCollection 2016. PLoS One. 2016. PMID: 27755550 Free PMC article.
Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline.
John C, Soler Artigas M, Hui J, Nielsen SF, Rafaels N, Paré PD, Hansel NN, Shrine N, Kilty I, Malarstig A, Jelinsky SA, Vedel-Krogh S, Barnes K, Hall IP, Beilby J, Musk AW, Nordestgaard BG, James A, Wain LV, Tobin MD. John C, et al. Among authors: kilty i. Thorax. 2017 May;72(5):400-408. doi: 10.1136/thoraxjnl-2016-208448. Epub 2017 Feb 7. Thorax. 2017. PMID: 28174340 Free PMC article.
Cigarette smoke induced airway inflammation is independent of NF-κB signalling.
Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, Lawrence T, Adcock IM, Belvisi MG, Birrell MA. Rastrick JM, et al. Among authors: kilty i. PLoS One. 2013;8(1):e54128. doi: 10.1371/journal.pone.0054128. Epub 2013 Jan 22. PLoS One. 2013. PMID: 23349803 Free PMC article.
Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.
Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP. Bewley MA, et al. Among authors: kilty i. Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC. Am J Respir Crit Care Med. 2018. PMID: 29547002 Free PMC article.
JAK-STAT pathway activation in COPD.
Yew-Booth L, Birrell MA, Lau MS, Baker K, Jones V, Kilty I, Belvisi MG. Yew-Booth L, et al. Among authors: kilty i. Eur Respir J. 2015 Sep;46(3):843-5. doi: 10.1183/09031936.00228414. Epub 2015 Jun 25. Eur Respir J. 2015. PMID: 26113679 Free article. No abstract available.
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