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HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.
Ramos-Montoya A, Lamb AD, Russell R, Carroll T, Jurmeister S, Galeano-Dalmau N, Massie CE, Boren J, Bon H, Theodorou V, Vias M, Shaw GL, Sharma NL, Ross-Adams H, Scott HE, Vowler SL, Howat WJ, Warren AY, Wooster RF, Mills IG, Neal DE. Ramos-Montoya A, et al. Among authors: scott he. EMBO Mol Med. 2014 May;6(5):651-61. doi: 10.1002/emmm.201303581. EMBO Mol Med. 2014. PMID: 24737870 Free PMC article.
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG. Massie CE, et al. EMBO J. 2011 May 20;30(13):2719-33. doi: 10.1038/emboj.2011.158. EMBO J. 2011. PMID: 21602788 Free PMC article.
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
Zecchini V, Madhu B, Russell R, Pértega-Gomes N, Warren A, Gaude E, Borlido J, Stark R, Ireland-Zecchini H, Rao R, Scott H, Boren J, Massie C, Asim M, Brindle K, Griffiths J, Frezza C, Neal DE, Mills IG. Zecchini V, et al. EMBO J. 2014 Jun 17;33(12):1365-82. doi: 10.15252/embj.201386874. Epub 2014 May 16. EMBO J. 2014. PMID: 24837709 Free PMC article.
Independence of HIF1a and androgen signaling pathways in prostate cancer.
Tran MGB, Bibby BAS, Yang L, Lo F, Warren AY, Shukla D, Osborne M, Hadfield J, Carroll T, Stark R, Scott H, Ramos-Montoya A, Massie C, Maxwell P, West CML, Mills IG, Neal DE. Tran MGB, et al. BMC Cancer. 2020 May 25;20(1):469. doi: 10.1186/s12885-020-06890-6. BMC Cancer. 2020. PMID: 32450824 Free PMC article.
Pro-neural transcription factors as cancer markers.
Vias M, Massie CE, East P, Scott H, Warren A, Zhou Z, Nikitin AY, Neal DE, Mills IG. Vias M, et al. BMC Med Genomics. 2008 May 19;1:17. doi: 10.1186/1755-8794-1-17. BMC Med Genomics. 2008. PMID: 18489756 Free PMC article.
High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53.
Veerakumarasivam A, Scott HE, Chin SF, Warren A, Wallard MJ, Grimmer D, Ichimura K, Caldas C, Collins VP, Neal DE, Kelly JD. Veerakumarasivam A, et al. Among authors: scott he. Clin Cancer Res. 2008 May 1;14(9):2527-34. doi: 10.1158/1078-0432.CCR-07-4129. Clin Cancer Res. 2008. PMID: 18451213 Free article.
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