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The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis.
Holzinger D, Frosch M, Kastrup A, Prince FH, Otten MH, Van Suijlekom-Smit LW, ten Cate R, Hoppenreijs EP, Hansmann S, Moncrieffe H, Ursu S, Wedderburn LR, Roth J, Foell D, Wittkowski H. Holzinger D, et al. Among authors: roth j. Ann Rheum Dis. 2012 Jun;71(6):974-80. doi: 10.1136/annrheumdis-2011-200598. Epub 2012 Jan 20. Ann Rheum Dis. 2012. PMID: 22267331
Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease.
Kienhorst LB, van Lochem E, Kievit W, Dalbeth N, Merriman ME, Phipps-Green A, Loof A, van Heerde W, Vermeulen S, Stamp LK, van Koolwijk E, de Graaf J, Holzinger D, Roth J, Janssens HJ, Merriman TR, Broen JC, Janssen M, Radstake TR. Kienhorst LB, et al. Among authors: roth j. Arthritis Rheumatol. 2015 Dec;67(12):3303-13. doi: 10.1002/art.39318. Arthritis Rheumatol. 2015. PMID: 26248007
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.
Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: roth j. Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480. Epub 2014 Sep 1. Ann Rheum Dis. 2016. PMID: 25180294
MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes.
Wittkowski H, Kuemmerle-Deschner JB, Austermann J, Holzinger D, Goldbach-Mansky R, Gramlich K, Lohse P, Jung T, Roth J, Benseler SM, Foell D. Wittkowski H, et al. Among authors: roth j. Ann Rheum Dis. 2011 Dec;70(12):2075-2081. doi: 10.1136/ard.2011.152496. Epub 2011 Sep 8. Ann Rheum Dis. 2011. PMID: 21908452 Free PMC article.
Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis.
Mahler EA, Zweers MC, van Lent PL, Blom AB, van den Hoogen FH, van den Berg WB, Roth J, Vogl T, Bijlsma JW, van den Ende CH, den Broeder AA. Mahler EA, et al. Among authors: roth j. Scand J Rheumatol. 2015;44(1):56-60. doi: 10.3109/03009742.2014.918176. Epub 2014 Sep 2. Scand J Rheumatol. 2015. PMID: 25179566
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.
Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: roth j. Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12. Ann Rheum Dis. 2015. PMID: 25969431
4,865 results