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Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
Kormos CM, Gichinga MG, Maitra R, Runyon SP, Thomas JB, Brieaddy LE, Mascarella SW, Navarro HA, Carroll FI. Kormos CM, et al. Among authors: gichinga mg. J Med Chem. 2014 Sep 11;57(17):7367-81. doi: 10.1021/jm5008177. Epub 2014 Aug 25. J Med Chem. 2014. PMID: 25133923 Free PMC article.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Kormos CM, Gichinga MG, Runyon SP, Thomas JB, Mascarella SW, Decker AM, Navarro HA, Carroll FI. Kormos CM, et al. Among authors: gichinga mg. Bioorg Med Chem. 2016 Aug 15;24(16):3842-8. doi: 10.1016/j.bmc.2016.06.029. Epub 2016 Jun 15. Bioorg Med Chem. 2016. PMID: 27364611 Free PMC article.
15 results