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A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin.
Schurek EM, Völker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, Höhne M. Schurek EM, et al. Among authors: chalfie m. J Biol Chem. 2014 Apr 18;289(16):11262-11271. doi: 10.1074/jbc.M113.521773. Epub 2014 Mar 4. J Biol Chem. 2014. PMID: 24596097 Free PMC article.
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.
Huber TB, Schermer B, Müller RU, Höhne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstädt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T. Huber TB, et al. Among authors: chalfie m. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17079-86. doi: 10.1073/pnas.0607465103. Epub 2006 Nov 1. Proc Natl Acad Sci U S A. 2006. PMID: 17079490 Free PMC article.
Regulation of the epithelial Na+ channel by paraoxonase-2.
Shi S, Buck TM, Kinlough CL, Marciszyn AL, Hughey RP, Chalfie M, Brodsky JL, Kleyman TR. Shi S, et al. Among authors: chalfie m. J Biol Chem. 2017 Sep 22;292(38):15927-15938. doi: 10.1074/jbc.M117.785253. Epub 2017 Aug 2. J Biol Chem. 2017. PMID: 28768768 Free PMC article.
126 results