Shackelford DB - Search Results

1

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. Faubert B, et al. Among authors: shackelford db. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2554-9. doi: 10.1073/pnas.1312570111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24550282 Free PMC article.

2

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.

Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. Shackelford DB, et al. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11137-42. doi: 10.1073/pnas.0900465106. Epub 2009 Jun 18. Proc Natl Acad Sci U S A. 2009. PMID: 19541609 Free PMC article.

3

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.

Shackelford DB, Shaw RJ. Shackelford DB, et al. Nat Rev Cancer. 2009 Aug;9(8):563-75. doi: 10.1038/nrc2676. Nat Rev Cancer. 2009. PMID: 19629071 Free PMC article.

4

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Gwinn DM, et al. Among authors: shackelford db. Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003. Mol Cell. 2008. PMID: 18439900 Free PMC article.

5

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.

Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. Shackelford DB, et al. Cancer Cell. 2013 Feb 11;23(2):143-58. doi: 10.1016/j.ccr.2012.12.008. Epub 2013 Jan 24. Cancer Cell. 2013. PMID: 23352126 Free PMC article.

6

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models.

Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU. Eichner LJ, et al. Among authors: shackelford db. Cell Metab. 2019 Feb 5;29(2):285-302.e7. doi: 10.1016/j.cmet.2018.10.005. Epub 2018 Nov 8. Cell Metab. 2019. PMID: 30415923 Free PMC article.

7

Hypoxia induces a phase transition within a kinase signaling network in cancer cells.

Wei W, Shi Q, Remacle F, Qin L, Shackelford DB, Shin YS, Mischel PS, Levine RD, Heath JR. Wei W, et al. Among authors: shackelford db. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1352-60. doi: 10.1073/pnas.1303060110. Epub 2013 Mar 25. Proc Natl Acad Sci U S A. 2013. PMID: 23530221 Free PMC article.

8

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Egan DF, et al. Among authors: shackelford db. Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23. Science. 2011. PMID: 21205641 Free PMC article.

9

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.

Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. Hsieh MH, et al. Among authors: shackelford db. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027. Cell Rep. 2019. PMID: 31412252 Free PMC article.

10

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.

Momcilovic M, Shackelford DB. Momcilovic M, et al. Among authors: shackelford db. Br J Cancer. 2015 Aug 11;113(4):574-84. doi: 10.1038/bjc.2015.261. Epub 2015 Jul 21. Br J Cancer. 2015. PMID: 26196184 Free PMC article. Review.

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