Leon LJ - Search Results

1

Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB.

Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL 3rd, Gomes AV, Baar K, Weiss RH, Hammock BD. Wecksler AT, et al. Among authors: leon lj. Anticancer Drugs. 2014 Apr;25(4):433-46. doi: 10.1097/CAD.0000000000000079. Anticancer Drugs. 2014. PMID: 24525589 Free PMC article.

2

A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells.

Leon LJ, Pasupuleti N, Gorin F, Carraway KL 3rd. Leon LJ, et al. PLoS One. 2013 Apr 30;8(4):e63038. doi: 10.1371/journal.pone.0063038. Print 2013. PLoS One. 2013. PMID: 23646172 Free PMC article.

3

Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells.

Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway KL 3rd. Rowson-Hodel AR, et al. Among authors: leon lj. Cancer Lett. 2016 May 28;375(1):62-72. doi: 10.1016/j.canlet.2016.02.042. Epub 2016 Mar 2. Cancer Lett. 2016. PMID: 26944316 Free PMC article.

4

5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor.

Pasupuleti N, Leon L, Carraway KL 3rd, Gorin F. Pasupuleti N, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15. doi: 10.1124/jpet.112.200519. Epub 2012 Dec 14. J Pharmacol Exp Ther. 2013. PMID: 23241369 Free PMC article.

5

Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.

Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL 3rd, Lyeth B, Gorin FA. Harley W, et al. Brain Res. 2010 Dec 2;1363:159-69. doi: 10.1016/j.brainres.2010.09.059. Epub 2010 Oct 13. Brain Res. 2010. PMID: 20869350 Free PMC article.

6

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.

Wu CY, Wang DH, Wang X, Dixon SM, Meng L, Ahadi S, Enter DH, Chen CY, Kato J, Leon LJ, Ramirez LM, Maeda Y, Reis CF, Ribeiro B, Weems B, Kung HJ, Lam KS. Wu CY, et al. Among authors: leon lj. ACS Comb Sci. 2016 Jun 13;18(6):320-9. doi: 10.1021/acscombsci.5b00194. Epub 2016 May 3. ACS Comb Sci. 2016. PMID: 27053324 Free PMC article.

7

Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.

Moyzis AG, Lally NS, Liang W, Leon LJ, Najor RH, Orogo AM, Gustafsson ÅB. Moyzis AG, et al. Among authors: leon lj. J Mol Cell Cardiol. 2020 Sep;146:109-120. doi: 10.1016/j.yjmcc.2020.07.009. Epub 2020 Jul 25. J Mol Cell Cardiol. 2020. PMID: 32717194 Free PMC article.

8

Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.

Hammerling BC, Shires SE, Leon LJ, Cortez MQ, Gustafsson ÅB. Hammerling BC, et al. Among authors: leon lj. Small GTPases. 2020 Jan;11(1):69-76. doi: 10.1080/21541248.2017.1342749. Epub 2017 Sep 18. Small GTPases. 2020. PMID: 28696827 Free PMC article.

9

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.

Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA, Gustafsson ÅB. Lampert MA, et al. Among authors: leon lj. Autophagy. 2019 Jul;15(7):1182-1198. doi: 10.1080/15548627.2019.1580095. Epub 2019 Feb 22. Autophagy. 2019. PMID: 30741592 Free PMC article.

10

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.

Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW II, Sadoshima J, Ellisman MH, Gustafsson ÅB. Hammerling BC, et al. Among authors: leon lj. Nat Commun. 2017 Jan 30;8:14050. doi: 10.1038/ncomms14050. Nat Commun. 2017. PMID: 28134239 Free PMC article.

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