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Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Butts A, et al. Among authors: krysan dj. mBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13. mBio. 2014. PMID: 24520056 Free PMC article.
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. Miron-Ocampo A, et al. Among authors: krysan dj. bioRxiv [Preprint]. 2023 May 1:2023.05.01.538946. doi: 10.1101/2023.05.01.538946. bioRxiv. 2023. Update in: Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23. PMID: 37205554 Free PMC article. Updated. Preprint.
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. Miron-Ocampo A, et al. Among authors: krysan dj. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23. Epub 2023 Sep 13. Antimicrob Agents Chemother. 2023. PMID: 37702508 Free PMC article.
Novel Keto-Alkyl-Pyridinium Antifungal Molecules Active in Models of In Vivo Candida albicans Vascular Catheter Infection and Ex Vivo Candida auris Skin Colonization.
Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Beattie SR, et al. Among authors: krysan dj. Antimicrob Agents Chemother. 2023 May 17;67(5):e0008123. doi: 10.1128/aac.00081-23. Epub 2023 Apr 25. Antimicrob Agents Chemother. 2023. PMID: 37097144 Free PMC article.
Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo Candida albicans vascular catheter infection and ex vivo Candida auris skin colonization.
Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Beattie SR, et al. Among authors: krysan dj. bioRxiv [Preprint]. 2023 Jan 20:2023.01.19.524835. doi: 10.1101/2023.01.19.524835. bioRxiv. 2023. Update in: Antimicrob Agents Chemother. 2023 May 17;67(5):e0008123. doi: 10.1128/aac.00081-23. PMID: 36711909 Free PMC article. Updated. Preprint.
117 results