Mendillo ML - Search Results

1

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J. Filone CM, et al. Among authors: mendillo ml. PLoS Pathog. 2014 Feb 6;10(2):e1003904. doi: 10.1371/journal.ppat.1003904. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24516381 Free PMC article.

2

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. Santagata S, et al. Among authors: mendillo ml. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. doi: 10.1073/pnas.1115031108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042860 Free PMC article.

3

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.

Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. Mendillo ML, et al. Cell. 2012 Aug 3;150(3):549-62. doi: 10.1016/j.cell.2012.06.031. Cell. 2012. PMID: 22863008 Free PMC article.

4

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.

Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S. Santagata S, et al. Among authors: mendillo ml. Science. 2013 Jul 19;341(6143):1238303. doi: 10.1126/science.1238303. Science. 2013. PMID: 23869022 Free PMC article.

5

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S. Scherz-Shouval R, et al. Among authors: mendillo ml. Cell. 2014 Jul 31;158(3):564-78. doi: 10.1016/j.cell.2014.05.045. Cell. 2014. PMID: 25083868 Free PMC article.

6

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.

Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S. Whitesell L, et al. Among authors: mendillo ml. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18297-302. doi: 10.1073/pnas.1421323111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489079 Free PMC article.

7

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S. Tsvetkov P, et al. Among authors: mendillo ml. Elife. 2015 Sep 1;4:e08467. doi: 10.7554/eLife.08467. Elife. 2015. PMID: 26327695 Free PMC article.

8

HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.

Smith RS, Takagishi SR, Amici DR, Metz K, Gayatri S, Alasady MJ, Wu Y, Brockway S, Taiberg SL, Khalatyan N, Taipale M, Santagata S, Whitesell L, Lindquist S, Savas JN, Mendillo ML. Smith RS, et al. Among authors: mendillo ml. Sci Adv. 2022 Mar 18;8(11):eabj6526. doi: 10.1126/sciadv.abj6526. Epub 2022 Mar 16. Sci Adv. 2022. PMID: 35294249 Free PMC article.

9

An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress.

Alasady MJ, Koeva M, Takagishi SR, Segal D, Amici DR, Smith RS, Ansel DJ, Lindquist S, Whitesell L, Bartom ET, Taipale M, Mendillo ML. Alasady MJ, et al. Among authors: mendillo ml. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2313370121. doi: 10.1073/pnas.2313370121. Epub 2024 Jul 10. Proc Natl Acad Sci U S A. 2024. PMID: 38985769

10

The Multifaceted Role of HSF1 in Tumorigenesis.

Alasady MJ, Mendillo ML. Alasady MJ, et al. Among authors: mendillo ml. Adv Exp Med Biol. 2020;1243:69-85. doi: 10.1007/978-3-030-40204-4_5. Adv Exp Med Biol. 2020. PMID: 32297212 Free PMC article. Review.

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