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Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.
Payeli SK, Kollnberger S, Marroquin Belaunzaran O, Thiel M, McHugh K, Giles J, Shaw J, Kleber S, Ridley A, Wong-Baeza I, Keidel S, Kuroki K, Maenaka K, Wadle A, Renner C, Bowness P. Payeli SK, et al. Among authors: mchugh k. Arthritis Rheum. 2012 Oct;64(10):3139-49. doi: 10.1002/art.34538. Arthritis Rheum. 2012. PMID: 22576154 Free article.
KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis.
Wong-Baeza I, Ridley A, Shaw J, Hatano H, Rysnik O, McHugh K, Piper C, Brackenbridge S, Fernandes R, Chan A, Bowness P, Kollnberger S. Wong-Baeza I, et al. Among authors: mchugh k. J Immunol. 2013 Apr 1;190(7):3216-24. doi: 10.4049/jimmunol.1202926. Epub 2013 Feb 25. J Immunol. 2013. PMID: 23440420 Free PMC article.
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.
Cauli A, Shaw J, Giles J, Hatano H, Rysnik O, Payeli S, McHugh K, Dessole G, Porru G, Desogus E, Fiedler S, Hölper S, Carette A, Blanco-Gelaz MA, Vacca A, Piga M, Ibba V, Garau P, La Nasa G, López-Larrea C, Mathieu A, Renner C, Bowness P, Kollnberger S. Cauli A, et al. Among authors: mchugh k. Rheumatology (Oxford). 2013 Nov;52(11):1952-62. doi: 10.1093/rheumatology/ket219. Epub 2013 Jun 26. Rheumatology (Oxford). 2013. PMID: 23804219 Free PMC article.
590 results