Ives JL - Search Results

1

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.

Fuller NO, Hubbs JL, Austin WF, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives JL, Findeis MA, Bronk BS. Fuller NO, et al. Among authors: ives jl. ACS Med Chem Lett. 2012 Aug 29;3(11):908-13. doi: 10.1021/ml300256p. eCollection 2012 Nov 8. ACS Med Chem Lett. 2012. PMID: 24900406 Free PMC article.

2

5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.

Villalobos A, Butler TW, Chapin DS, Chen YL, DeMattos SB, Ives JL, Jones SB, Liston DR, Nagel AA, Nason DM, et al. Villalobos A, et al. Among authors: ives jl. J Med Chem. 1995 Jul 21;38(15):2802-8. doi: 10.1021/jm00015a002. J Med Chem. 1995. PMID: 7636841

3

Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.

Nagel AA, Liston DR, Jung S, Mahar M, Vincent LA, Chapin D, Chen YL, Hubbard S, Ives JL, Jones SB, et al. Nagel AA, et al. Among authors: ives jl. J Med Chem. 1995 Mar 31;38(7):1084-9. doi: 10.1021/jm00007a005. J Med Chem. 1995. PMID: 7707311

4

Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.

Villalobos A, Blake JF, Biggers CK, Butler TW, Chapin DS, Chen YL, Ives JL, Jones SB, Liston DR, Nagel AA, et al. Villalobos A, et al. Among authors: ives jl. J Med Chem. 1994 Aug 19;37(17):2721-34. doi: 10.1021/jm00043a012. J Med Chem. 1994. PMID: 8064800

5

Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.

Rosen T, Seeger TF, McLean S, Nagel AA, Ives JL, Guarino KJ, Bryce D, Furman J, Roth RW, Chalabi PM, et al. Rosen T, et al. Among authors: ives jl. J Med Chem. 1990 Nov;33(11):3020-3. doi: 10.1021/jm00173a017. J Med Chem. 1990. PMID: 2231600

6

Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.

Rosen T, Nagel AA, Rizzi JP, Ives JL, Daffeh JB, Ganong AH, Guarino K, Heym J, McLean S, Nowakowski JT, et al. Rosen T, et al. Among authors: ives jl. J Med Chem. 1990 Oct;33(10):2715-20. doi: 10.1021/jm00172a006. J Med Chem. 1990. PMID: 2213824

7

3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.

Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, Nielsen JA, Ryan K, Schulz DW, Torgersen LK, et al. Macor JE, et al. Among authors: ives jl. J Med Chem. 1990 Aug;33(8):2087-93. doi: 10.1021/jm00170a007. J Med Chem. 1990. PMID: 2374139

8

Developmental status of synthetic immunomodulators.

Berendt MJ, Ives JL. Berendt MJ, et al. Among authors: ives jl. Year Immunol. 1985:193-201. Year Immunol. 1985. PMID: 2437723 Review. No abstract available.

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