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SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Wright Colopy G, Dreau H, Sigaux F, Judde JG, Rotger M, Telenti A, Lin YL, Pasero P, Maelfait J, Titsias M, Cohen DR, Henderson SJ, Ross MT, Bentley D, Hillmen P, Pettitt A, Rehwinkel J, Knight SJ, Taylor JC, Crow YJ, Benkirane M, Schuh A. Clifford R, et al. Among authors: benkirane m. Blood. 2014 Feb 13;123(7):1021-31. doi: 10.1182/blood-2013-04-490847. Epub 2013 Dec 12. Blood. 2014. PMID: 24335234 Free PMC article.
SAMHD1 acts at stalled replication forks to prevent interferon induction.
Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P. Coquel F, et al. Among authors: benkirane m. Nature. 2018 May;557(7703):57-61. doi: 10.1038/s41586-018-0050-1. Epub 2018 Apr 18. Nature. 2018. PMID: 29670289
[SAMHD1 acts at stalled replication forks to prevent interferon induction].
Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P. Coquel F, et al. Among authors: benkirane m. C R Biol. 2020 Jun 5;343(1):9-21. doi: 10.5802/crbiol.10. C R Biol. 2020. PMID: 32720483 Free article. Review. French.
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells.
Descours B, Cribier A, Chable-Bessia C, Ayinde D, Rice G, Crow Y, Yatim A, Schwartz O, Laguette N, Benkirane M. Descours B, et al. Among authors: benkirane m. Retrovirology. 2012 Oct 23;9:87. doi: 10.1186/1742-4690-9-87. Retrovirology. 2012. PMID: 23092122 Free PMC article.
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.
Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck J, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A, Benkirane M. Laguette N, et al. Among authors: benkirane m. Cell Host Microbe. 2012 Feb 16;11(2):205-17. doi: 10.1016/j.chom.2012.01.007. Epub 2012 Feb 1. Cell Host Microbe. 2012. PMID: 22305291 Free PMC article.
Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.
Wittmann S, Behrendt R, Eissmann K, Volkmann B, Thomas D, Ebert T, Cribier A, Benkirane M, Hornung V, Bouzas NF, Gramberg T. Wittmann S, et al. Among authors: benkirane m. Retrovirology. 2015 Dec 15;12:103. doi: 10.1186/s12977-015-0229-6. Retrovirology. 2015. PMID: 26667483 Free PMC article.
How SAMHD1 changes our view of viral restriction.
Laguette N, Benkirane M. Laguette N, et al. Among authors: benkirane m. Trends Immunol. 2012 Jan;33(1):26-33. doi: 10.1016/j.it.2011.11.002. Epub 2011 Dec 15. Trends Immunol. 2012. PMID: 22177690 Free PMC article. Review.
Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.
Bermejo M, López-Huertas MR, García-Pérez J, Climent N, Descours B, Ambrosioni J, Mateos E, Rodríguez-Mora S, Rus-Bercial L, Benkirane M, Miró JM, Plana M, Alcamí J, Coiras M. Bermejo M, et al. Among authors: benkirane m. Biochem Pharmacol. 2016 Apr 15;106:30-45. doi: 10.1016/j.bcp.2016.02.002. Epub 2016 Feb 4. Biochem Pharmacol. 2016. PMID: 26851491
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
De Meo S, Dell'Oste V, Molfetta R, Tassinari V, Lotti LV, Vespa S, Pignoloni B, Covino DA, Fantuzzi L, Bona R, Zingoni A, Nardone I, Biolatti M, Coscia A, Paolini R, Benkirane M, Edfors F, Sandalova T, Achour A, Hiscott J, Landolfo S, Santoni A, Cerboni C. De Meo S, et al. Among authors: benkirane m. PLoS Pathog. 2020 Sep 28;16(9):e1008855. doi: 10.1371/journal.ppat.1008855. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32986788 Free PMC article.
139 results