Duckett D - Search Results

1

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

He Y, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Ruiz CH, Lograsso PV, Kamenecka TM, Koenig M. He Y, et al. Among authors: duckett d. Bioorg Med Chem Lett. 2014 Jan 1;24(1):161-4. doi: 10.1016/j.bmcl.2013.11.052. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332487 Free PMC article.

2

Synthesis of potent bicyclic bisarylimidazole c-Jun N-terminal kinase inhibitors by catalytic C-H bond activation.

Rech JC, Yato M, Duckett D, Ember B, LoGrasso PV, Bergman RG, Ellman JA. Rech JC, et al. Among authors: duckett d. J Am Chem Soc. 2007 Jan 24;129(3):490-1. doi: 10.1021/ja0676004. J Am Chem Soc. 2007. PMID: 17227002 Free PMC article.

3

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

Jiang R, Duckett D, Chen W, Habel J, Ling YY, LoGrasso P, Kamenecka TM. Jiang R, et al. Among authors: duckett d. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6378-82. doi: 10.1016/j.bmcl.2007.08.054. Epub 2007 Aug 26. Bioorg Med Chem Lett. 2007. PMID: 17911023

4

Chroman-3-amides as potent Rho kinase inhibitors.

Chen YT, Bannister TD, Weiser A, Griffin E, Lin L, Ruiz C, Cameron MD, Schürer S, Duckett D, Schröter T, LoGrasso P, Feng Y. Chen YT, et al. Among authors: duckett d. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6406-9. doi: 10.1016/j.bmcl.2008.10.080. Epub 2008 Oct 22. Bioorg Med Chem Lett. 2008. PMID: 18990570

5

Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.

Kamenecka T, Habel J, Duckett D, Chen W, Ling YY, Frackowiak B, Jiang R, Shin Y, Song X, LoGrasso P. Kamenecka T, et al. Among authors: duckett d. J Biol Chem. 2009 May 8;284(19):12853-61. doi: 10.1074/jbc.M809430200. Epub 2009 Mar 4. J Biol Chem. 2009. PMID: 19261605 Free PMC article.

6

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.

Shin Y, Chen W, Habel J, Duckett D, Ling YY, Koenig M, He Y, Vojkovsky T, LoGrasso P, Kamenecka TM. Shin Y, et al. Among authors: duckett d. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3344-7. doi: 10.1016/j.bmcl.2009.03.086. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19433357 Free PMC article.

7

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

Yin Y, Lin L, Ruiz C, Cameron MD, Pocas J, Grant W, Schröter T, Chen W, Duckett D, Schürer S, Lograsso P, Feng Y. Yin Y, et al. Among authors: duckett d. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6686-90. doi: 10.1016/j.bmcl.2009.09.115. Epub 2009 Oct 3. Bioorg Med Chem Lett. 2009. PMID: 19837589

8

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J, Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV. Kamenecka T, et al. Among authors: duckett d. J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f. J Med Chem. 2010. PMID: 19947601 Free PMC article.

9

Metabolism considerations for kinase inhibitors in cancer treatment.

Duckett DR, Cameron MD. Duckett DR, et al. Expert Opin Drug Metab Toxicol. 2010 Oct;6(10):1175-93. doi: 10.1517/17425255.2010.506873. Expert Opin Drug Metab Toxicol. 2010. PMID: 20684746 Free PMC article. Review.

10

Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.

Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Kumar N, et al. Among authors: duckett dr. ACS Chem Biol. 2011 Mar 18;6(3):218-22. doi: 10.1021/cb1002762. Epub 2010 Dec 6. ACS Chem Biol. 2011. PMID: 21090593 Free PMC article.

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