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The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.
Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, Simen BB, St John EP, Chan-Hui PY, Swiderek K, Kleinstein SH, Alter G, Seaman MS, Chakraborty AK, Koller D, Wilson IA, Church GM, Burton DR, Poignard P. Sok D, et al. Among authors: chakraborty ak. PLoS Pathog. 2013;9(11):e1003754. doi: 10.1371/journal.ppat.1003754. Epub 2013 Nov 21. PLoS Pathog. 2013. PMID: 24278016 Free PMC article. Clinical Trial.
Effective membrane model of the immunological synapse.
Raychaudhuri S, Chakraborty AK, Kardar M. Raychaudhuri S, et al. Among authors: chakraborty ak. Phys Rev Lett. 2003 Nov 14;91(20):208101. doi: 10.1103/PhysRevLett.91.208101. Epub 2003 Nov 10. Phys Rev Lett. 2003. PMID: 14683399
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Mouquet H, et al. Among authors: chakraborty ak. Nature. 2010 Sep 30;467(7315):591-5. doi: 10.1038/nature09385. Nature. 2010. PMID: 20882016 Free PMC article.
Quorum sensing allows T cells to discriminate between self and nonself.
Butler TC, Kardar M, Chakraborty AK. Butler TC, et al. Among authors: chakraborty ak. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11833-8. doi: 10.1073/pnas.1222467110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818603 Free PMC article.
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. Barouch DH, et al. Among authors: chakraborty ak. Nature. 2013 Nov 14;503(7475):224-8. doi: 10.1038/nature12744. Epub 2013 Oct 30. Nature. 2013. PMID: 24172905 Free PMC article.
396 results