Chen T - Search Results

1

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH. Chen T, et al. J Med Chem. 2013 Dec 12;56(23):9457-70. doi: 10.1021/jm400793v. Epub 2013 Nov 27. J Med Chem. 2013. PMID: 24261904 Free PMC article.

2

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target.

Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH. Chen T, et al. Among authors: chen l. Nat Chem Biol. 2011 Jul 17;7(9):610-6. doi: 10.1038/nchembio.613. Nat Chem Biol. 2011. PMID: 21765405 Free PMC article.

3

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: chen l, chen t. Bioorg Med Chem Lett. 2012 Jan 1;22(1):402-9. doi: 10.1016/j.bmcl.2011.10.126. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22153346 Free PMC article.

4

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Denoyelle S, Chen T, Yang H, Chen L, Zhang Y, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: chen l, chen t. Eur J Med Chem. 2013 Nov;69:537-53. doi: 10.1016/j.ejmech.2013.08.030. Epub 2013 Sep 17. Eur J Med Chem. 2013. PMID: 24095748

5

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M. Takrouri K, et al. Among authors: chen t, chen h. Eur J Med Chem. 2014 Apr 22;77:361-77. doi: 10.1016/j.ejmech.2014.03.034. Epub 2014 Mar 13. Eur J Med Chem. 2014. PMID: 24675136 Free PMC article.

6

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.

Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Mahalingam P, et al. Among authors: chen l, chen t. J Med Chem. 2014 Jun 26;57(12):5094-111. doi: 10.1021/jm401733v. Epub 2014 Jun 4. J Med Chem. 2014. PMID: 24827861 Free PMC article.

7

Dual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.

Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH. Bai H, et al. Among authors: chen t. Chembiochem. 2013 Jul 8;14(10):1255-62. doi: 10.1002/cbic.201300177. Epub 2013 Jun 19. Chembiochem. 2013. PMID: 23784735 Free PMC article.

8

3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.

Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M. Yefidoff-Freedman R, et al. Among authors: chen l, chen t. Chembiochem. 2014 Mar 3;15(4):595-611. doi: 10.1002/cbic.201300723. Epub 2014 Jan 23. Chembiochem. 2014. PMID: 24458973 Free PMC article.

9

Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.

Ziegeler G, Ming J, Koseki JC, Sevinc S, Chen T, Ergun S, Qin X, Aktas BH. Ziegeler G, et al. Among authors: chen t. J Biol Chem. 2010 May 14;285(20):15408-15419. doi: 10.1074/jbc.M110.113365. Epub 2010 Mar 23. J Biol Chem. 2010. PMID: 20332085 Free PMC article.

10

Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.

Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X. Wu G, et al. Among authors: chen t. Circulation. 2010 Mar 23;121(11):1338-46. doi: 10.1161/CIRCULATIONAHA.108.844589. Epub 2010 Mar 8. Circulation. 2010. PMID: 20212283 Free PMC article.

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