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Page 1
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T. Okada-Iwabu M, et al. Nature. 2013 Nov 28;503(7477):493-9. doi: 10.1038/nature12656. Epub 2013 Oct 30. Nature. 2013. PMID: 24172895
Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.
Bin BH, Hojyo S, Hosaka T, Bhin J, Kano H, Miyai T, Ikeda M, Kimura-Someya T, Shirouzu M, Cho EG, Fukue K, Kambe T, Ohashi W, Kim KH, Seo J, Choi DH, Nam YJ, Hwang D, Fukunaka A, Fujitani Y, Yokoyama S, Superti-Furga A, Ikegawa S, Lee TR, Fukada T. Bin BH, et al. EMBO Mol Med. 2014 Aug;6(8):1028-42. doi: 10.15252/emmm.201303809. EMBO Mol Med. 2014. PMID: 25007800 Free PMC article.
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.
Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, Fukuyama T, Tomita T, Iwatsubo T. Takeo K, et al. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10544-9. doi: 10.1073/pnas.1402171111. Epub 2014 Jul 9. Proc Natl Acad Sci U S A. 2014. PMID: 25009180 Free PMC article.
Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2.
Tanabe H, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hosaka T, Hato M, Fujii Y, Nakamura Y, Ogasawara S, Hino T, Murata T, Iwata S, Okada-Iwabu M, Iwabu M, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S. Tanabe H, et al. J Struct Funct Genomics. 2015 Mar;16(1):11-23. doi: 10.1007/s10969-014-9192-z. Epub 2015 Jan 10. J Struct Funct Genomics. 2015. PMID: 25575462 Free PMC article.
Crystal structures of the human adiponectin receptors.
Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S. Tanabe H, et al. Nature. 2015 Apr 16;520(7547):312-316. doi: 10.1038/nature14301. Epub 2015 Apr 8. Nature. 2015. PMID: 25855295 Free PMC article.
Cell-free methods to produce structurally intact mammalian membrane proteins.
Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S. Shinoda T, et al. Sci Rep. 2016 Jul 28;6:30442. doi: 10.1038/srep30442. Sci Rep. 2016. PMID: 27465719 Free PMC article.
37 results