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Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism.
Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Ali N, et al. Among authors: chandrakesan p. PLoS One. 2013 Nov 19;8(11):e80304. doi: 10.1371/journal.pone.0080304. eCollection 2013. PLoS One. 2013. PMID: 24260365 Free PMC article.
Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury.
Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett T, Houchen CW. Qu D, et al. Among authors: chandrakesan p. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G404-11. doi: 10.1152/ajpgi.00088.2013. Epub 2013 Dec 24. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 24368703 Free PMC article.
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW. Sureban SM, et al. Among authors: chandrakesan p. Cancer Lett. 2014 Aug 28;351(1):151-61. doi: 10.1016/j.canlet.2014.05.011. Epub 2014 May 28. Cancer Lett. 2014. PMID: 24880079
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma.
Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW. Weygant N, et al. Among authors: chandrakesan p. Oncotarget. 2015 Feb 10;6(4):2193-205. doi: 10.18632/oncotarget.3059. Oncotarget. 2015. PMID: 25605241 Free PMC article.
Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells.
Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW. Qu D, et al. Among authors: chandrakesan p. PLoS One. 2015 Feb 27;10(2):e0118933. doi: 10.1371/journal.pone.0118933. eCollection 2015. PLoS One. 2015. PMID: 25723399 Free PMC article.
39 results