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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.
Nat Genet. 2013 Nov;45(11):1386-91. doi: 10.1038/ng.2777. Epub 2013 Sep 29.
Nat Genet. 2013.
PMID: 24076604
Free PMC article.
NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.
Huang Z, Wu H, Chuai S, Xu F, Yan F, Englund N, Wang Z, Zhang H, Fang M, Wang Y, Gu J, Zhang M, Yang T, Zhao K, Yu Y, Dai J, Yi W, Zhou S, Li Q, Wu J, Liu J, Wu X, Chan H, Lu C, Atadja P, Li E, Wang Y, Hu M.
Huang Z, et al.
Cancer Res. 2013 Oct 15;73(20):6277-88. doi: 10.1158/0008-5472.CAN-13-1000. Epub 2013 Aug 26.
Cancer Res. 2013.
PMID: 23980095
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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.
Pan S, Wu X, Jiang J, Gao W, Wan Y, Cheng D, Han D, Liu J, Englund NP, Wang Y, Peukert S, Miller-Moslin K, Yuan J, Guo R, Matsumoto M, Vattay A, Jiang Y, Tsao J, Sun F, Pferdekamper AC, Dodd S, Tuntland T, Maniara W, Kelleher JF 3rd, Yao YM, Warmuth M, Williams J, Dorsch M.
Pan S, et al. Among authors: englund np.
ACS Med Chem Lett. 2010 Mar 16;1(3):130-4. doi: 10.1021/ml1000307. eCollection 2010 Jun 10.
ACS Med Chem Lett. 2010.
PMID: 24900187
Free PMC article.
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Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.
Tao H, Jin Q, Koo DI, Liao X, Englund NP, Wang Y, Ramamurthy A, Schultz PG, Dorsch M, Kelleher J, Wu X.
Tao H, et al. Among authors: englund np.
Chem Biol. 2011 Apr 22;18(4):432-7. doi: 10.1016/j.chembiol.2011.01.018.
Chem Biol. 2011.
PMID: 21513879
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Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists.
Cheng D, Han D, Gao W, Jing Q, Jiang J, Wan Y, Englund NP, Tuntland T, Wu X, Pan S.
Cheng D, et al. Among authors: englund np.
Bioorg Med Chem Lett. 2012 Nov 1;22(21):6573-6. doi: 10.1016/j.bmcl.2012.09.013. Epub 2012 Sep 13.
Bioorg Med Chem Lett. 2012.
PMID: 23036954
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Essential role of stromally induced hedgehog signaling in B-cell malignancies.
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M.
Dierks C, et al. Among authors: englund np.
Nat Med. 2007 Aug;13(8):944-51. doi: 10.1038/nm1614. Epub 2007 Jul 15.
Nat Med. 2007.
PMID: 17632527
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NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta.
Coudronniere N, Villalba M, Englund N, Altman A.
Coudronniere N, et al.
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3394-9. doi: 10.1073/pnas.97.7.3394.
Proc Natl Acad Sci U S A. 2000.
PMID: 10716728
Free PMC article.
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