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Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound.
Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Moss D, Thomson TA, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA, Ruuth E. Williamson RA, et al. Among authors: kuo ea. J Biol Chem. 1995 Sep 22;270(38):22467-72. doi: 10.1074/jbc.270.38.22467. J Biol Chem. 1995. PMID: 7673235 Free article.
Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.
Kuo EA, Hambleton PT, Kay DP, Evans PL, Matharu SS, Little E, McDowall N, Jones CB, Hedgecock CJ, Yea CM, Chan AW, Hairsine PW, Ager IR, Tully WR, Williamson RA, Westwood R. Kuo EA, et al. J Med Chem. 1996 Nov 8;39(23):4608-21. doi: 10.1021/jm9604437. J Med Chem. 1996. PMID: 8917650
Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide.
Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA, Ruuth E. Williamson RA, et al. Among authors: kuo ea. Transplant Proc. 1996 Dec;28(6):3088-91. Transplant Proc. 1996. PMID: 8962196 No abstract available.
204 results