Dennis MD - Search Results

1

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).

Dennis MD, McGhee NK, Jefferson LS, Kimball SR. Dennis MD, et al. Cell Signal. 2013 Dec;25(12):2709-16. doi: 10.1016/j.cellsig.2013.08.038. Epub 2013 Sep 7. Cell Signal. 2013. PMID: 24018049 Free PMC article.

2

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

Dennis MD, Baum JI, Kimball SR, Jefferson LS. Dennis MD, et al. J Biol Chem. 2011 Mar 11;286(10):8287-8296. doi: 10.1074/jbc.M110.209171. Epub 2011 Jan 14. J Biol Chem. 2011. PMID: 21239491 Free PMC article.

3

Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.

Dennis MD, Schrufer TL, Bronson SK, Kimball SR, Jefferson LS. Dennis MD, et al. J Biol Chem. 2011 Sep 30;286(39):34286-97. doi: 10.1074/jbc.M111.259457. Epub 2011 Aug 12. J Biol Chem. 2011. PMID: 21840999 Free PMC article.

4

Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.

Dennis MD, Jefferson LS, Kimball SR. Dennis MD, et al. J Biol Chem. 2012 Dec 14;287(51):42890-9. doi: 10.1074/jbc.M112.404822. Epub 2012 Oct 26. J Biol Chem. 2012. PMID: 23105104 Free PMC article.

5

Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.

Dennis MD, Kimball SR, Jefferson LS. Dennis MD, et al. J Biol Chem. 2013 Jan 4;288(1):10-9. doi: 10.1074/jbc.M112.402461. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184952 Free PMC article.

6

The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.

Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS. Kelleher AR, et al. Among authors: dennis md. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E229-36. doi: 10.1152/ajpendo.00409.2012. Epub 2012 Nov 27. Am J Physiol Endocrinol Metab. 2013. PMID: 23193052 Free PMC article.

7

Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism.

Dennis MD, Shenberger JS, Stanley BA, Kimball SR, Jefferson LS. Dennis MD, et al. Diabetes. 2013 Jul;62(7):2204-14. doi: 10.2337/db12-1453. Epub 2013 Feb 22. Diabetes. 2013. PMID: 23434932 Free PMC article.

8

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR. Gordon BS, et al. Among authors: dennis md. Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3. Cell Signal. 2014. PMID: 24316235 Free PMC article.

9

mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.

Martin TD, Dennis MD, Gordon BS, Kimball SR, Jefferson LS. Martin TD, et al. Among authors: dennis md. Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1397-405. doi: 10.1152/ajpendo.00064.2014. Epub 2014 May 6. Am J Physiol Endocrinol Metab. 2014. PMID: 24801387 Free PMC article.

10

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR. Dennis MD, et al. Sci Signal. 2014 Jul 22;7(335):ra68. doi: 10.1126/scisignal.2005103. Sci Signal. 2014. PMID: 25056877 Free PMC article.

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