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AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
Bruhn MA, Pearson RB, Hannan RD, Sheppard KE. Bruhn MA, et al. Among authors: hannan rd. Cancer Manag Res. 2013 Aug 26;5:281-92. doi: 10.2147/CMAR.S35178. eCollection 2013. Cancer Manag Res. 2013. PMID: 24009430 Free PMC article. Review.
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, Hannan RD. Hannan KM, et al. Among authors: hannan rd. Mol Cell Biol. 2003 Dec;23(23):8862-77. doi: 10.1128/MCB.23.23.8862-8877.2003. Mol Cell Biol. 2003. PMID: 14612424 Free PMC article.
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.
Poortinga G, Hannan KM, Snelling H, Walkley CR, Jenkins A, Sharkey K, Wall M, Brandenburger Y, Palatsides M, Pearson RB, McArthur GA, Hannan RD. Poortinga G, et al. Among authors: hannan km, hannan rd. EMBO J. 2004 Aug 18;23(16):3325-35. doi: 10.1038/sj.emboj.7600335. Epub 2004 Jul 29. EMBO J. 2004. PMID: 15282543 Free PMC article.
UBF levels determine the number of active ribosomal RNA genes in mammals.
Sanij E, Poortinga G, Sharkey K, Hung S, Holloway TP, Quin J, Robb E, Wong LH, Thomas WG, Stefanovsky V, Moss T, Rothblum L, Hannan KM, McArthur GA, Pearson RB, Hannan RD. Sanij E, et al. Among authors: hannan km, hannan rd. J Cell Biol. 2008 Dec 29;183(7):1259-74. doi: 10.1083/jcb.200805146. Epub 2008 Dec 22. J Cell Biol. 2008. PMID: 19103806 Free PMC article.
Second AKT: the rise of SGK in cancer signalling.
Bruhn MA, Pearson RB, Hannan RD, Sheppard KE. Bruhn MA, et al. Among authors: hannan rd. Growth Factors. 2010 Dec;28(6):394-408. doi: 10.3109/08977194.2010.518616. Epub 2010 Oct 5. Growth Factors. 2010. PMID: 20919962 Review.
140 results