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Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.
Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben S, Bentley P, Wright T, Patel V. Lee EC, et al. Among authors: androsavich jr. Nat Commun. 2019 Sep 12;10(1):4148. doi: 10.1038/s41467-019-11918-y. Nat Commun. 2019. PMID: 31515477 Free PMC article.
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism.
Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson JA, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V. Hajarnis S, et al. Among authors: androsavich jr. Nat Commun. 2017 Feb 16;8:14395. doi: 10.1038/ncomms14395. Nat Commun. 2017. PMID: 28205547 Free PMC article.
12 results