Yang H - Search Results

1

Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.

Roethle PA, McFadden RM, Yang H, Hrvatin P, Hui H, Graupe M, Gallagher B, Chao J, Hesselgesser J, Duatschek P, Zheng J, Lu B, Tumas DB, Perry J, Halcomb RL. Roethle PA, et al. Among authors: yang h. J Med Chem. 2013 Sep 26;56(18):7324-33. doi: 10.1021/jm400815m. Epub 2013 Sep 9. J Med Chem. 2013. PMID: 23961878

2

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.

Washburn WN, Manfredi M, Devasthale P, Zhao G, Ahmad S, Hernandez A, Robl JA, Wang W, Mignone J, Wang Z, Ngu K, Pelleymounter MA, Longhi D, Zhao R, Wang B, Huang N, Flynn N, Azzara AV, Barrish JC, Rohrbach K, Devenny JJ, Rooney S, Thomas M, Glick S, Godonis HE, Harvey SJ, Cullen MJ, Zhang H, Caporuscio C, Stetsko P, Grubb M, Maxwell BD, Yang H, Apedo A, Gemzik B, Janovitz EB, Huang C, Zhang L, Freeden C, Murphy BJ. Washburn WN, et al. Among authors: yang h. J Med Chem. 2014 Sep 25;57(18):7509-22. doi: 10.1021/jm500026w. Epub 2014 Sep 9. J Med Chem. 2014. PMID: 25165888

3

Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives.

Robins MJ, Yang H, Miranda K, Peterson MA, De Clercq E, Balzarini J. Robins MJ, et al. Among authors: yang h. J Med Chem. 2009 May 14;52(9):3018-27. doi: 10.1021/jm900203h. J Med Chem. 2009. PMID: 19378989

4

Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2.

Wei J, Shi Q, Li B, Yang H, Liu L, Zhou R, Feng Z, Yang Z, Zhan J, Xiong XF, Huang X, Wang Y. Wei J, et al. Among authors: yang h, yang z. J Med Chem. 2024 Sep 26;67(18):16056-16071. doi: 10.1021/acs.jmedchem.4c00639. Epub 2024 Sep 4. J Med Chem. 2024. PMID: 39230932

5

Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors.

Chen Y, Wang Z, Zhang J, Shi Q, Yang H, Deng Y, Wang X, Liu T, Geng M, Xiong B, Huang X. Chen Y, et al. Among authors: yang h. Eur J Med Chem. 2024 Mar 5;267:116171. doi: 10.1016/j.ejmech.2024.116171. Epub 2024 Jan 28. Eur J Med Chem. 2024. PMID: 38301329

6

Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors.

Yang C, Li B, Feng Z, Li H, Yang H, Yang Z, Liu L, Shi Q, Wang H, Chen ZZ, Huang X, Wang J, Wang Y. Yang C, et al. Among authors: yang h, yang z. J Med Chem. 2024 Sep 26;67(18):16072-16087. doi: 10.1021/acs.jmedchem.4c00640. Epub 2024 Jul 15. J Med Chem. 2024. PMID: 39008565

7

Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma.

Chen Z, Yang H, Zhang Y, Lyu X, Shi Q, Zhang C, Wang X, Wang Z, Zhang Y, Deng Y, Wang Y, Huang Y, Xu Y, Huang X, Li Y. Chen Z, et al. Among authors: yang h. J Med Chem. 2024 Oct 24;67(20):18606-18628. doi: 10.1021/acs.jmedchem.4c01984. Epub 2024 Oct 2. J Med Chem. 2024. PMID: 39356741

8

Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2.

Zhang Y, Yang H, Li B, Li J, Li H, Shi Q, Li B, Wang Z, Zheng J, Zhang Y, Dong H, Huang X, Wang Y. Zhang Y, et al. Among authors: yang h. J Med Chem. 2023 Jun 8;66(11):7629-7644. doi: 10.1021/acs.jmedchem.3c00504. Epub 2023 May 19. J Med Chem. 2023. PMID: 37203326

9

One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors.

Li H, Yang H, Liu L, Zheng J, Shi Q, Li B, Wang X, Zhang Y, Zhou R, Zhang J, Chen ZZ, Wang CY, Wang Y, Huang X, Liu Z. Li H, et al. Among authors: yang h. Eur J Med Chem. 2025 Jan 5;281:116970. doi: 10.1016/j.ejmech.2024.116970. Epub 2024 Oct 19. Eur J Med Chem. 2025. PMID: 39488968

10

Correction to "Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors".

Yang C, Li B, Feng Z, Li H, Yang H, Yang Z, Liu L, Shi Q, Wang H, Chen ZZ, Huang X, Wang J, Wang Y. Yang C, et al. Among authors: yang h, yang z. J Med Chem. 2024 Oct 24;67(20):18629. doi: 10.1021/acs.jmedchem.4c02417. Epub 2024 Oct 15. J Med Chem. 2024. PMID: 39405460 No abstract available.

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