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Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.
Hanker AB, Pfefferle AD, Balko JM, Kuba MG, Young CD, Sánchez V, Sutton CR, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL. Hanker AB, et al. Among authors: cheng h. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14372-7. doi: 10.1073/pnas.1303204110. Epub 2013 Aug 12. Proc Natl Acad Sci U S A. 2013. PMID: 23940356 Free PMC article.
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.
Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ. Cheng H, et al. Sci Signal. 2009 Jul 21;2(80):ra35. doi: 10.1126/scisignal.2000369. Sci Signal. 2009. PMID: 19622832 Free PMC article.
Targeting the phosphoinositide 3-kinase pathway in cancer.
Liu P, Cheng H, Roberts TM, Zhao JJ. Liu P, et al. Among authors: cheng h. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. doi: 10.1038/nrd2926. Nat Rev Drug Discov. 2009. PMID: 19644473 Free PMC article. Review.
Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Young CD, Pfefferle AD, Owens P, Kuba MG, Rexer BN, Balko JM, Sánchez V, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL. Young CD, et al. Among authors: cheng h. Cancer Res. 2013 Jul 1;73(13):4075-85. doi: 10.1158/0008-5472.CAN-12-4579. Epub 2013 Apr 30. Cancer Res. 2013. PMID: 23633485 Free PMC article.
Chemopreventive effects of aspirin at a glance.
Usman MW, Luo F, Cheng H, Zhao JJ, Liu P. Usman MW, et al. Among authors: cheng h. Biochim Biophys Acta. 2015 Apr;1855(2):254-63. doi: 10.1016/j.bbcan.2015.03.007. Epub 2015 Apr 2. Biochim Biophys Acta. 2015. PMID: 25842298 Review.
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