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An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon.
Spivey VL, Whalan RH, Hirst EM, Smerdon SJ, Buxton RS. Spivey VL, et al. Among authors: buxton rs. FEMS Microbiol Lett. 2013 Oct;347(2):107-15. doi: 10.1111/1574-6968.12230. Epub 2013 Aug 23. FEMS Microbiol Lett. 2013. PMID: 23915284 Free PMC article.
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS. Lougheed KE, et al. Among authors: buxton rs. Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/j.tube.2011.03.005. Epub 2011 Apr 11. Tuberculosis (Edinb). 2011. PMID: 21482481 Free PMC article.
A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.
Rickman L, Scott C, Hunt DM, Hutchinson T, Menéndez MC, Whalan R, Hinds J, Colston MJ, Green J, Buxton RS. Rickman L, et al. Among authors: buxton rs. Mol Microbiol. 2005 Jun;56(5):1274-86. doi: 10.1111/j.1365-2958.2005.04609.x. Mol Microbiol. 2005. PMID: 15882420 Free PMC article.
106 results