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SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.
Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R. Toiber D, et al. Among authors: mulligan p. Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018. Epub 2013 Aug 1. Mol Cell. 2013. PMID: 23911928 Free PMC article.
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Walker AK, et al. Among authors: mulligan p. Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210. Genes Dev. 2010. PMID: 20595232 Free PMC article.
Functional antagonism between histone H3K4 demethylases in vivo.
Di Stefano L, Walker JA, Burgio G, Corona DF, Mulligan P, Näär AM, Dyson NJ. Di Stefano L, et al. Among authors: mulligan p. Genes Dev. 2011 Jan 1;25(1):17-28. doi: 10.1101/gad.1983711. Genes Dev. 2011. PMID: 21205864 Free PMC article.
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM. Mulligan P, et al. Mol Cell. 2011 Jun 10;42(5):689-99. doi: 10.1016/j.molcel.2011.04.020. Epub 2011 May 19. Mol Cell. 2011. PMID: 21596603 Free PMC article.
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.
Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Keller PJ, Glover E, Richardson AL, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Näär AM, Blasco MA, Hinds PW, Kuperwasser C. Sedic M, et al. Among authors: mulligan p. Nat Commun. 2015 Jun 24;6:7505. doi: 10.1038/ncomms8505. Nat Commun. 2015. PMID: 26106036 Free PMC article.
73 results